Down-Regulated NOD2 by Immunosuppressants in Peripheral Blood Cells in Patients with SLE Reduces the Muramyl Dipeptide-Induced IL-10 Production

• Published in: PloS one Vol. 6; no. 8; p. e23855
• Main Authors: Yu, Shui-Lian, Wong, Chun-Kwok, Wong, Purple Tsz-Yan, Chen, Da-Peng, Szeto, Cheuk-Chun, Li, Edmund K., Tam, Lai-Shan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.08.2011; Public Library of Science (PLoS)
• Subjects: Acetylmuramyl-Alanyl-Isoglutamine - pharmacology; Adult; Analysis; Autoimmune diseases; B cells; Bacteria; Bacterial diseases; Bacterial infections; Blood; Blood cells; Blood Cells - drug effects; Blood Cells - immunology; Blood Cells - metabolism; Case-Control Studies; CD8 antigen; Cervical cancer; Chronic conditions; Crohn's disease; Crohns disease; Cytokines; Cytokines - biosynthesis; Dendritic cells; Development and progression; Down-Regulation - drug effects; Flow cytometry; Health risks; Hepatitis; Hospitals; Human papillomavirus; Humans; Immune response; Immune system; Immune System - pathology; Immunity, Innate; Immunosuppressive agents; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - pharmacology; Immunotherapy; Infections; Inflammation; Innate immunity; Interleukin 10; Interleukin 6; Interleukin 8; Interleukin-10 - biosynthesis; Leukocytes (mononuclear); Ligands; Lupus; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - immunology; Lymphocytes; Lymphocytes B; Lymphocytes T; Medical research; Medical treatment; Medicine; Middle Aged; Monocytes; Muramyl dipeptide; Mutation; Mycobacterium tuberculosis; NOD2 protein; Nod2 Signaling Adaptor Protein - drug effects; Nod2 Signaling Adaptor Protein - genetics; Oligomerization; Oligomers; Overexpression; Pathogenesis; Pathology; Patients; Pattern recognition; Pattern recognition receptors; Peripheral blood mononuclear cells; Production management; Proteins; Receptors; Rheumatoid arthritis; Rheumatology; Rodents; Somatotropin; Systemic lupus erythematosus; T cells; Therapy; Toll-like receptors; Tuberculosis; Young Adult; Hong Kong China; United Kingdom > UK; China; Wales

Pattern recognition receptors (PRRs) such as Toll-like receptors are aberrantly expressed of peripheral blood mononuclear cells (PBMCs) in systemic lupus erythematosus (SLE) patients, for playing immunopathological roles. We investigated the expression and function of the PRR nucleotide-binding olig...