Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease: Longitudinal Findings from the Heart and Soul Study

• Published in: PloS one Vol. 5; no. 1; p. e8612
• Main Authors: Farzaneh-Far, Ramin, Lin, Jue, Epel, Elissa, Lapham, Kyle, Blackburn, Elizabeth, Whooley, Mary A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.01.2010; Public Library of Science (PLoS)
• Subjects: Age; Aging; Aging (natural); Base pairs; Base Sequence; Biochemistry; Biophysics; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Disorders/Coronary Artery Disease; Cardiovascular Disorders/Geriatric Cardiology; Cell division; Chromosomes; Cohort Studies; Coronary artery; Coronary artery disease; Coronary Artery Disease - genetics; Coronary heart disease; Coronary vessels; Deoxyribonucleic acid; DNA; DNA polymerase; DNA Primers; Genetic testing; Geriatrics/Geriatric Cardiology; Health aspects; Health risk assessment; Heart; Heart attacks; Heart diseases; Hip; Human subjects; Humans; Hypertension; Longitudinal Studies; Medical research; Morbidity; Mortality; Multivariate Analysis; Negative feedback; Obesity; Oxidative stress; Population; Prognosis; Public Health and Epidemiology/Epidemiology; R&D; Regression analysis; Regression models; Research & development; Senescence; Sex; Studies; Telomerase; Telomere; Telomeres; Trajectories; Trends; United States > US; San Francisco Bay; California

Leukocyte telomere length, an emerging marker of biological age, has been shown to predict cardiovascular morbidity and mortality. However, the natural history of telomere length in patients with coronary artery disease has not been studied. We sought to investigate the longitudinal trajectory of te...