Small GTPase patterning: How to stabilise cluster coexistence

• Published in: PloS one Vol. 14; no. 3; p. e0213188
• Main Authors: Jacobs, Bas, Molenaar, Jaap, Deinum, Eva E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.03.2019; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Biometris (WU MAT); Cell membranes; EPS; Fungal Proteins - chemistry; Fungal Proteins - metabolism; Fungi - metabolism; Genetic aspects; GTPases; Mathematical and Statistical Methods - Biometris; Models, Molecular; Monomeric GTP-Binding Proteins - chemistry; Monomeric GTP-Binding Proteins - metabolism; PE&RC; Physical Sciences; Physiological aspects; Proteins; Research and Analysis Methods; Wiskundige en Statistische Methoden - Biometris; Netherlands

Many biological processes have to occur at specific locations on the cell membrane. These locations are often specified by the localised activity of small GTPase proteins. Some processes require the formation of a single cluster of active GTPase, also called unipolar polarisation (here "polaris...