Barcoded Pyrosequencing Reveals That Consumption of Galactooligosaccharides Results in a Highly Specific Bifidogenic Response in Humans

• Published in: PloS one Vol. 6; no. 9; p. e25200
• Main Authors: Davis, Lauren M. G., Martínez, Inés, Walter, Jens, Goin, Caitlin, Hutkins, Robert W.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.09.2011; Public Library of Science (PLoS)
• Subjects: Adults; Bacteria; Bacteroides; Bacteroides - drug effects; Bacteroides - genetics; Bakeries; Bifidobacterium - drug effects; Bifidobacterium - genetics; Biology; Carbohydrates; Change detection; Cichorium; Cynara scolymus; DNA sequencing; DNA, Ribosomal; Enrichment; Fecal microflora; Feces; Feces - microbiology; Fermentation; Food science; Galactooligosaccharides; Gastrointestinal system; Gastrointestinal tract; Gastrointestinal Tract - microbiology; High-Throughput Nucleotide Sequencing - methods; Human subjects; Intestinal microflora; Intestine; Lactobacillus; Medicine; Microbiota (Symbiotic organisms); Multiplexing; Oligosaccharides - pharmacology; Prebiotics; Probiotics; rRNA 16S; Tags; United States > US; Nebraska

Prebiotics are selectively fermented ingredients that allow specific changes in the gastrointestinal microbiota that confer health benefits to the host. However, the effects of prebiotics on the human gut microbiota are incomplete as most studies have relied on methods that fail to cover the breadth...