Progression of biopsy-measured liver fibrosis in untreated patients with hepatitis C infection: non-Markov multistate model analysis

• Published in: PloS one Vol. 6; no. 5; p. e20104
• Main Authors: Bacchetti, Peter, Boylan, Ross, Astemborski, Jacquie, Shen, Hui, Mehta, Shruti H, Thomas, David L, Terrault, Norah A, Monto, Alexander
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.05.2011; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; African Americans; Age; Aging - pathology; AIDS; Alcohol use; Antiretroviral agents; Biopsy; Confidence intervals; Disease Progression; Fibrosis; Geriatrics; Health risks; Hepatitis; Hepatitis C; Hepatitis C - complications; Highly active antiretroviral therapy; HIV; HIV infections; Human immunodeficiency virus; Humans; Infection; Infections; Interferon; Liver; Liver - pathology; Liver Cirrhosis - complications; Liver Cirrhosis - pathology; Liver transplants; Markov Chains; Mathematics; Measurement; Medicine; Middle Aged; Models, Biological; Race; Risk analysis; Risk Factors; Risk reduction; Sensitivity and Specificity; Time Factors; Viruses; Young Adult; San Francisco California; California; United States > US; Maryland; Baltimore Maryland

Fibrosis stages from liver biopsies reflect liver damage from hepatitis C infection, but analysis is challenging due to their ordered but non-numeric nature, infrequent measurement, misclassification, and unknown infection times. We used a non-Markov multistate model, accounting for misclassificatio...