liver-enriched gene 1a and 1b Encode Novel Secretory Proteins Essential for Normal Liver Development in Zebrafish

• Published in: PloS one Vol. 6; no. 8; p. e22910
• Main Authors: Chang, Changqing, Hu, Minjie, Zhu, Zhihui, Lo, Li Jan, Chen, Jun, Peng, Jinrong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.08.2011; Public Library of Science (PLoS)
• Subjects: Amino Acid Sequence; Animal sciences; Animals; Base Sequence; Biology; Blotting, Western; Cell cycle; Cell Cycle Checkpoints - genetics; Danio rerio; Embryo, Nonmammalian - embryology; Embryo, Nonmammalian - metabolism; Endoderm; Enrichment; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Genes; Growth rate; In Situ Hybridization; Intestine; Laboratory animals; Larva - genetics; Larva - growth & development; Larva - metabolism; Larvae; Liver; Liver - embryology; Liver - growth & development; Liver - metabolism; Liver diseases; Luminescent Proteins - genetics; Luminescent Proteins - metabolism; Markers; Medicine; Microscopy, Fluorescence; Molecular Sequence Data; Morphogenesis; Pancreas; Phenotypes; Phylogeny; Protein Isoforms - genetics; Protein Isoforms - metabolism; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA polymerase; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Studies; Time Factors; Vertebrates; Veterinary Science; Zebrafish; Zebrafish - embryology; Zebrafish - genetics; Zebrafish - growth & development; Zebrafish - metabolism; Zebrafish Proteins - classification; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism; United States > US; China

liver-enriched gene 1 (leg1) is a liver-enriched gene in zebrafish and encodes a novel protein. Our preliminary data suggested that Leg1 is probably involved in early liver development. However, no detailed characterization of Leg1 has been reported thus far. We undertook both bioinformatic and expe...