A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer

• Published in: BMC cancer Vol. 18; no. 1; pp. 596 - 9
• Main Authors: Hirooka, Yoshiki, Kasuya, Hideki, Ishikawa, Takuya, Kawashima, Hiroki, Ohno, Eizaburo, Villalobos, Itzel B., Naoe, Yoshinori, Ichinose, Toru, Koyama, Nobuto, Tanaka, Maki, Kodera, Yasuhiro, Goto, Hidemi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.05.2018; BioMed Central; BMC
• Subjects: Adult; Aged; Analysis; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Antitumor activity; Cancer therapies; Care and treatment; Chemotherapy; Clinical trials; Combined Modality Therapy - adverse effects; Combined Modality Therapy - methods; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Drug dosages; Duodenum; Endosonography; Erlotinib Hydrochloride - therapeutic use; EUS-guidance; Female; Gemcitabine; Herpes simplex; Herpesvirus 1, Human - genetics; HF10; Humans; Injection; Injections, Intralesional - methods; Male; Medical prognosis; Metastasis; Middle Aged; Mutation; Myelosuppression; Oncolysis; Oncolytic viral therapy; Oncolytic Virotherapy - adverse effects; Oncolytic Virotherapy - methods; Oncolytic virus; Oncolytic Viruses - genetics; Pancreas - diagnostic imaging; Pancreas - pathology; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - therapy; Patients; Prognosis; Progression-Free Survival; Survival; Survival Rate; Toxicity; Treatment Outcome; Tumors; Ultrasonography, Interventional; Ultrasound; Young Adult; Oncolytic virus; EUS-guidance; HF10; Pancreatic cancer

Prognosis of pancreatic cancer is poor with a 5-year survival rate of only 7%. Although several new chemotherapy treatments have shown promising results, all patients will eventually progress, and we need to develop newer chemotherapy treatments to improve response rates and overall survival (OS). H...