Genome-scale consequences of cofactor balancing in engineered pentose utilization pathways in Saccharomyces cerevisiae

• Published in: PloS one Vol. 6; no. 11; p. e27316
• Main Authors: Ghosh, Amit, Zhao, Huimin, Price, Nathan D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.11.2011; Public Library of Science (PLoS)
• Subjects: Arabinose; Arabinose - metabolism; Baking yeast; Batch production; Biodiesel fuels; Biofuels; Biology; Biomass; Biomass energy; Biomass energy production; Biophysics; Cofactors; Computer simulation; Dehydrogenases; Dynamic models; E coli; Earth Sciences; Energy sources; Engineering; Enzymes; Escherichia coli; Ethanol; Ethanol - metabolism; Ethanol fuels; Fermentation; Fungi; Gene expression; Genetic Engineering; Genome, Fungal - genetics; Genomes; Genomics; Glucose; Glucose - metabolism; Growth rate; Helicobacter pylori; Hexose; Lignocellulose; Metabolic Networks and Pathways; Metabolism; Microorganisms; NAD - metabolism; NADP - metabolism; Pentose; Pentoses - metabolism; Proteins; Renewable Energy; Renewable energy sources; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - growth & development; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Sugar; Utilization; Xylose; Xylose - metabolism; Yeast; United States > US; Illinois

Biofuels derived from lignocellulosic biomass offer promising alternative renewable energy sources for transportation fuels. Significant effort has been made to engineer Saccharomyces cerevisiae to efficiently ferment pentose sugars such as D-xylose and L-arabinose into biofuels such as ethanol thro...