Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects

• Published in: PloS one Vol. 5; no. 7; p. e11428
• Main Authors: Tam, Claudia Ha Ting, Ho, Janice Sin Ka, Wang, Ying, Lee, Heung Man, Lam, Vincent Kwok Lim, Germer, Soren, Martin, Mitchell, So, Wing Yee, Ma, Ronald Ching Wan, Chan, Juliana Chung Ngor, Ng, Maggie Chor Yin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.07.2010; Public Library of Science (PLoS)
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adenosine; Adolescents; Adult; Adults; Alleles; Analysis; Asian Continental Ancestry Group - genetics; Beta cells; Binding sites; Blood Glucose - metabolism; Blood proteins; Catalysis; Chromosomes; Circadian rhythm; Diabetes; Diabetes and Endocrinology/Type 2 Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Fasting; Fasting - blood; Female; Gene expression; Gene loci; Genes; Genetic aspects; Genetics and Genomics/Complex Traits; Genetics and Genomics/Genetics of Disease; Genetics and Genomics/Medical Genetics; Genetics and Genomics/Population Genetics; Genomics; Genotype; Glucokinase; Glucokinase - genetics; Glucose; Glucose-6-Phosphatase - genetics; Homeostasis; Hospitals; Humans; Hyperglycemia; Insulin; Insulin secretion; Insulin-Secreting Cells - pathology; Insulin-Secreting Cells - physiology; Isoenzymes; Laboratory testing; Male; Medicine; Melatonin; Meta-analysis; Middle Aged; Pancreatic beta cells; Phosphatases; Plasma; Polymorphism, Single Nucleotide - genetics; Receptors, Melatonin - genetics; Rodents; Secretion; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Type 2 diabetes; Hong Kong China; United States > US; China; New Jersey

Previous studies identified melatonin receptor 1B (MTNR1B), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2), glucokinase (GCK) and glucokinase regulatory protein (GCKR) as candidate genes for type 2 diabetes (T2D) acting through elevated fasting plasma glucose (FPG). W...