Polyfunctional Specific Response to Echinococcus Granulosus Associates to the Biological Activity of the Cysts

• Published in: PLOS Neglected Tropical Diseases Vol. 9; no. 11; p. e0004209
• Main Authors: Petrone, Linda, Vanini, Valentina, Petruccioli, Elisa, Ettorre, Giuseppe Maria, Schininà, Vincenzo, Busi Rizzi, Elisa, Ludovisi, Alessandra, Corpolongo, Angela, Ippolito, Giuseppe, Pozio, Edoardo, TEGGI, Antonella, Goletti, Delia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science (PLoS) 17.11.2015; Public Library of Science
• Subjects: Adult; Aged; Animals; Antigens; Arctic medicine. Tropical medicine; Biological activity; CD4-Positive T-Lymphocytes; CD4-Positive T-Lymphocytes - immunology; Cysts; Cytokines; Cytokines - metabolism; Development and progression; Echinococcosis; Echinococcosis - immunology; Echinococcus granulosus; Echinococcus granulosus - immunology; Female; Flow Cytometry; Humans; Immune response; Male; Middle Aged; Observations; Parasites; Parasitic diseases; Properties; Prospective Studies; Public aspects of medicine; RA1-1270; RC955-962; Research Article; Studies; T-Lymphocyte Subsets; T-Lymphocyte Subsets - immunology; Zoonoses

Cystic echinococcosis (CE) is a complex disease caused by Echinococcus granulosus (E.granulosus), and its immunophatogenesis is still not clearly defined. A peculiar feature of chronic CE is the coexistence of Th1 and Th2 responses. It has been suggested that Th1 cytokines are related to disease res...