HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies

• Published in: Journal of Immunology Research Vol. 2021; pp. 1 - 13
• Main Authors: Lv, Tingxia, Cao, Wei, Li, Taisheng
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 2021; John Wiley & Sons, Inc; Wiley
• Subjects: Acquired immune deficiency syndrome; AIDS; Anti-inflammatory agents; Antiretroviral drugs; Antiretroviral therapy; Antiretroviral Therapy, Highly Active - methods; Antiviral agents; Biomarkers; Cardiovascular disease; CD4 antigen; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - virology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - virology; Clinical trials; Cytokines; Cytomegalovirus; Development and progression; Drug therapy; Health aspects; Highly active antiretroviral therapy; HIV; HIV (Viruses); HIV infection; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV-1 - drug effects; HIV-1 - immunology; HIV-1 - physiology; Human immunodeficiency virus; Humans; Immunology; Infections; Inflammation; Inflammation - immunology; Inflammation - prevention & control; Inflammation - virology; Interferon; Lymphocyte Activation - drug effects; Lymphocyte Activation - immunology; Lymphocyte Count; Lymphocytes; Lymphocytes T; Pattern recognition; Proteins; Review; T cells; Virus Replication - drug effects; Virus Replication - immunology; Viruses; China

Although antiretroviral therapy effectively controls human immunodeficiency virus (HIV) replication, a residual chronic immune activation/inflammation persists throughout the disease. This aberrant immune activation and inflammation are considered an accelerator of non-AIDS-related events and one of...