Administration of L-type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential

• Published in: Emerging infectious diseases Vol. 31; no. 5; pp. 986 - 990
• Main Authors: Imamura, Morikazu, Hagiwara, Ken’ichi, Tobiume, Minoru, Ohno, Minako, Iguchi, Hiromi, Takatsuki, Hanae, Mori, Tsuyoshi, Atarashi, Ryuichiro, Shibata, Hiroaki, Ono, Fumiko
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.05.2025; Centers for Disease Control and Prevention
• Subjects: Administration of L-Type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential; Animals; Asymptomatic; Beef cattle; Bovine spongiform encephalopathy; Brain - metabolism; Brain - pathology; Brain research; Cattle; Creutzfeldt-Jakob disease; cynomolgus macaques; Disease transmission; Dispatch; Encephalopathy, Bovine Spongiform - metabolism; Encephalopathy, Bovine Spongiform - pathology; Encephalopathy, Bovine Spongiform - transmission; Genetic engineering; Health aspects; Humans; Immunohistochemistry; L-Type bovine spongiform encephalopathy; Lymphatic system; Macaca; Macaques; Monkeys & apes; Nervous system; oral transmission; Physiological aspects; Prions; Prions - administration & dosage; Prions - metabolism; Proteins; PrPSc Proteins - administration & dosage; PrPSc Proteins - metabolism; Risk factors; Seeds; Small intestine; Spinal cord; Spleen; Transgenic animals; Zoonoses; Zoonoses - transmission; Japan; Japan; bovine spongiform encephalopathy; cynomolgus macaques; Macaca fascicularis; L-Type bovine spongiform encephalopathy; zoonoses; prions; oral transmission

We administered L-type bovine spongiform encephalopathy prions to macaques to determine their potential for transmission to humans. After 75 months, no clinical symptoms appeared, and prions were undetectable in any tissue by Western blot or immunohistochemistry. Protein misfolding cyclic amplificat...