Administration of L-type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential

We administered L-type bovine spongiform encephalopathy prions to macaques to determine their potential for transmission to humans. After 75 months, no clinical symptoms appeared, and prions were undetectable in any tissue by Western blot or immunohistochemistry. Protein misfolding cyclic amplificat...

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Bibliographic Details
Published inEmerging infectious diseases Vol. 31; no. 5; pp. 986 - 990
Main Authors Imamura, Morikazu, Hagiwara, Ken’ichi, Tobiume, Minoru, Ohno, Minako, Iguchi, Hiromi, Takatsuki, Hanae, Mori, Tsuyoshi, Atarashi, Ryuichiro, Shibata, Hiroaki, Ono, Fumiko
Format Journal Article
LanguageEnglish
Published United States U.S. National Center for Infectious Diseases 01.05.2025
Centers for Disease Control and Prevention
Subjects
Administration of L-Type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential
Animals
Asymptomatic
Beef cattle
Bovine spongiform encephalopathy
Brain - metabolism
Brain - pathology
Brain research
Cattle
Creutzfeldt-Jakob disease
cynomolgus macaques
Disease transmission
Dispatch
Encephalopathy, Bovine Spongiform - metabolism
Encephalopathy, Bovine Spongiform - pathology
Encephalopathy, Bovine Spongiform - transmission
Genetic engineering
Health aspects
Humans
Immunohistochemistry
L-Type bovine spongiform encephalopathy
Lymphatic system
Macaca
Macaques
Monkeys & apes
Nervous system
oral transmission
Physiological aspects
Prions
Prions - administration & dosage
Prions - metabolism
Proteins
PrPSc Proteins - administration & dosage
PrPSc Proteins - metabolism
Risk factors
Seeds
Small intestine
Spinal cord
Spleen
Transgenic animals
Zoonoses
Zoonoses - transmission
Japan
Japan
bovine spongiform encephalopathy
cynomolgus macaques
Macaca fascicularis
L-Type bovine spongiform encephalopathy
zoonoses
prions
oral transmission
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Summary:We administered L-type bovine spongiform encephalopathy prions to macaques to determine their potential for transmission to humans. After 75 months, no clinical symptoms appeared, and prions were undetectable in any tissue by Western blot or immunohistochemistry. Protein misfolding cyclic amplification, however, revealed prions in the nerve and lymphoid tissues.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid3105.241257