The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption

• Published in: Bone (New York, N.Y.) Vol. 51; no. 5; pp. 902 - 912
• Main Authors: Charles, Julia F., Coury, Fabienne, Sulyanto, Rosalyn, Sitara, Despina, Wu, Jing, Brady, Nicholas, Tsang, Kelly, Sigrist, Kirsten, Tollefsen, Douglas M., He, Li, Storm, Daniel, Aliprantis, Antonios O.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.11.2012; Elsevier
• Subjects: Adenylyl Cyclases - genetics; Adenylyl Cyclases - metabolism; Animals; Arthritis; Biological and medical sciences; Blotting, Western; Bone cancer; Bone resorption; Bone Resorption - genetics; Cancer; Cell Differentiation - genetics; Cell Differentiation - physiology; Cells, Cultured; Cytokines; Data processing; DNA microarrays; Fundamental and applied biological sciences. Psychology; Gene array; Gene expression; Giant cells; Homeostasis; Lymphocytes T; Mice; Mutation; NFATC Transcription Factors - genetics; NFATC Transcription Factors - metabolism; NFATc1; NHEDC2; Oligonucleotide Array Sequence Analysis; Orthopedics; Osteoclast; Osteoclastogenesis; Osteoclasts; Osteoclasts - cytology; Osteoclasts - drug effects; Osteoclasts - metabolism; Osteoprogenitor cells; rab GTP-Binding Proteins - genetics; rab GTP-Binding Proteins - metabolism; RANK Ligand - pharmacology; ras Proteins - genetics; ras Proteins - metabolism; Real-Time Polymerase Chain Reaction; rhoC GTP-Binding Protein; Signal transduction; Skeleton and joints; Sodium-Hydrogen Exchangers - genetics; Sodium-Hydrogen Exchangers - metabolism; TRANCE protein; Transcription activation; Transcription factors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: osteoarticular system, musculoskeletal system; Bone resorption; Gene array; OCPs; Adcy3; Rab38; Serpind1; Nhedc2; Osteoclast; Nfatc1; Rhoc; ras homolog gene family member C; nuclear factor of activated T-cells c1; serpin peptidase inhibitor, clade D, member 1; adenylate cyclase 3; ras-related protein; Na +/H + exchanger-like domain-containing protein 2; osteoclast precursors; Messenger RNA; Morphology; NHEDC2; NFATc1

Osteoclasts are specialized secretory cells of the myeloid lineage important for normal skeletal homeostasis as well as pathologic conditions of bone including osteoporosis, inflammatory arthritis and cancer metastasis. Differentiation of these multinucleated giant cells from precursors is controlle...