Immunological Link Between Primary Graft Dysfunction and Chronic Lung Allograft Rejection

• Published in: The Annals of thoracic surgery Vol. 86; no. 1; pp. 189 - 197
• Main Authors: Bharat, Ankit, Kuo, Elbert, Steward, Nancy, Aloush, Aviva, Hachem, Ramsey, Trulock, Elbert P., Patterson, G. Alexander, Meyers, Bryan F., Mohanakumar, T.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.07.2008
• Subjects: Adult; Age Distribution; Aged; Biomarkers - blood; Bronchiolitis Obliterans - epidemiology; Bronchiolitis Obliterans - etiology; Bronchiolitis Obliterans - immunology; Cardiothoracic Surgery; Chronic Disease; Female; Follow-Up Studies; Graft Rejection - epidemiology; Graft Rejection - immunology; Histocompatibility Testing; HLA Antigens - analysis; HLA Antigens - immunology; Humans; Incidence; Isoantibodies - analysis; Isoantibodies - immunology; Lung Transplantation - adverse effects; Lung Transplantation - immunology; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Risk Assessment; Sex Distribution; Surgery; Time Factors; Tissue Donors; Transplantation, Homologous - adverse effects; Transplantation, Homologous - immunology; 12; IL; APC; HLA-DR; BOS; HLA; PGD; ISHLT; PBMC; human leukocyte antigen; human leukocyte antigen–donor; International Society for Heart and Lung Transplantation; interleukin; antigen presenting cells; peripheral blood mononuclear cell; primary graft dysfunction; broncholitis obliterans syndrome

Primary graft dysfunction (PGD) in the immediate post–lung transplant period strongly increases the risk of chronic rejection (broncholitis obliterans syndrome). Here, we hypothesized that PGD-induced inflammation augments alloimmunity, thereby predisposing to broncholitis obliterans syndrome. Prima...