Assessments of CYP-inhibition-based drug-drug interaction between vonoprazan and poziotinib in vitro and in vivo

• Published in: Pharmaceutical Biology Vol. 61; no. 1; pp. 356 - 361
• Main Authors: Zhou, Shan, Zhao, Fang-Ling, Wang, Shuang-Hu, Wang, Yi-Ran, Hong, Yun, Zhou, Quan, Geng, Pei-Wu, Luo, Qing-Feng, Cai, Jian-Ping, Dai, Da-Peng
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 31.12.2023; Informa UK Limited; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Animals; Biological Sciences; blood; Chromatography, Liquid; computer software; CYP3A4; drug inhibition; Drug interaction; Drug Interactions; liver microsomes; Metabolism; Metabolites; Microsomes; Microsomes, Liver - metabolism; Pharmacokinetics; Rats; Research Article; RM1-950; Statistical analysis; statistical models; tail; Tandem Mass Spectrometry; Therapeutics. Pharmacology; UPLC-MS/MS; pharmacokinetics; UPLC-MS/MS; drug inhibition; CYP3A4

Poziotinib and vonoprazan are two drugs mainly metabolized by CYP3A4. However, the drug-drug interaction between them is unknown. To study the interaction mechanism and pharmacokinetics of poziotinib on vonoprazan. In vitro experiments were performed with rat liver microsomes (RLMs) and the contents...