Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia by downregulating oncogenic transcriptional programs. CDK7 kinase as an anti-cancer target Pharmacological blockade of transcription is a poss...

Full description

Saved in:
Bibliographic Details
Published inNature (London) Vol. 511; no. 7511; pp. 616 - 620
Main Authors Kwiatkowski, Nicholas, Zhang, Tinghu, Rahl, Peter B., Abraham, Brian J., Reddy, Jessica, Ficarro, Scott B., Dastur, Anahita, Amzallag, Arnaud, Ramaswamy, Sridhar, Tesar, Bethany, Jenkins, Catherine E., Hannett, Nancy M., McMillin, Douglas, Sanda, Takaomi, Sim, Taebo, Kim, Nam Doo, Look, Thomas, Mitsiades, Constantine S., Weng, Andrew P., Brown, Jennifer R., Benes, Cyril H., Marto, Jarrod A., Young, Richard A., Gray, Nathanael S.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 31.07.2014
Nature Publishing Group
Subjects
38/61
45/15
59/5
631/154/555
631/67/1990/283
631/67/395
631/92/275
82/58
96/2
96/31
96/98
Analysis
Antineoplastic Agents - pharmacology
Cancer
Care and treatment
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Core Binding Factor Alpha 2 Subunit - metabolism
Crystal structure
Cyclin-Dependent Kinases - antagonists & inhibitors
Cysteine
Cysteine - metabolism
Enzyme Inhibitors - pharmacology
Experiments
Gene expression
Gene Expression Regulation, Neoplastic - drug effects
Genetic aspects
Genetic regulation
Genetic transcription
Health aspects
Humanities and Social Sciences
Humans
Jurkat Cells
Kinases
letter
Leukemia
multidisciplinary
Pharmacology
Phenylenediamines - pharmacology
Phosphorylation
Phosphorylation - drug effects
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - enzymology
Pyrimidines - pharmacology
Regression analysis
Science
Transcription factors
Online AccessGet full text

Cover

Abstract Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia by downregulating oncogenic transcriptional programs. CDK7 kinase as an anti-cancer target Pharmacological blockade of transcription is a possible means of targeting cancer cells. Direct pharmacological inhibition of transcription factors has proved problematic, so cyclin-dependent kinase (CDK) family members such as CDK7, which regulate transcription by phosphorylating the carboxy-terminal domain of RNA polymerase II, could provide more druggable targets. Here Nathanael Gray and colleagues use a cell-based screen to identify a novel transcriptional inhibitor, THZ1, that covalently targets CDK7 and has anti-proliferative activity in human T-cell acute lymphoblastic leukaemia cell lines and in a xenograft mouse model. THZ1 is a phenylaminopyrimidine that uses a mechanism combining ATP-site and allosteric covalent binding as a means of attaining potency and selectivity for CDK7. Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state 1 , but direct pharmacological inhibition of transcription factors has so far proven difficult 2 . However, the transcriptional machinery contains various enzymatic cofactors that can be targeted for the development of new therapeutic candidates 3 , including cyclin-dependent kinases (CDKs) 4 . Here we present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukaemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide analysis in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumour cells. Pharmacological modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumour types that are dependent on transcription for maintenance of the oncogenic state.
AbstractList Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state 1 , but direct pharmacological inhibition of transcription factors has thus far proven difficult 2 . However, the transcriptional machinery contains various enzymatic co-factors that can be targeted for development of new therapeutic candidates 3 , including cyclin-dependent kinases (CDKs) 4 . Here we present the discovery and characterization of the first covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell line profiling indicates that a subset of cancer cell lines, including T-ALL, exhibit exceptional sensitivity to THZ1. Genome-wide analysis in Jurkat T-ALL shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and this transcription factor’s key role in the core transcriptional regulatory circuitry of these tumor cells. Pharmacological modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumor types exhibiting extreme dependencies on transcription for maintenance of the oncogenic state.
Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state (1), but direct pharmacological inhibition of transcription factors has so far proven difficult (2). However, the transcriptional machinery contains various enzymatic cofactors that can be targeted for the development of new therapeutic candidates (3), including cyclin-dependent kinases (CDKs) (4). Here we present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukaemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide analysis in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumour cells. Pharmacological modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumour types that are dependent on transcription for maintenance of the oncogenic state.
Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacological inhibition of transcription factors has so far proven difficult. However, the transcriptional machinery contains various enzymatic cofactors that can be targeted for the development of new therapeutic candidates, including cyclin-dependent kinases (CDKs). Here we present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukaemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide analysis in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumour cells. Pharmacological modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumour types that are dependent on transcription for maintenance of the oncogenic state.
Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacological inhibition of transcription factors has so far proven difficult. However, the transcriptional machinery contains various enzymatic cofactors that can be targeted for the development of new therapeutic candidates, including cyclin-dependent kinases (CDKs). Here we present the discovery and characterization of a covalent CDK7 inhibitor,THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukaemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide analysis in Jurkat T-ALL cells shows that THZ1disproportionally affects transcription of RUNX1 and suggests that sensitivity toTHZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumour cells. Pharmacological modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumour types that are dependent on transcription for maintenance of the oncogenic state.
Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia by downregulating oncogenic transcriptional programs. CDK7 kinase as an anti-cancer target Pharmacological blockade of transcription is a possible means of targeting cancer cells. Direct pharmacological inhibition of transcription factors has proved problematic, so cyclin-dependent kinase (CDK) family members such as CDK7, which regulate transcription by phosphorylating the carboxy-terminal domain of RNA polymerase II, could provide more druggable targets. Here Nathanael Gray and colleagues use a cell-based screen to identify a novel transcriptional inhibitor, THZ1, that covalently targets CDK7 and has anti-proliferative activity in human T-cell acute lymphoblastic leukaemia cell lines and in a xenograft mouse model. THZ1 is a phenylaminopyrimidine that uses a mechanism combining ATP-site and allosteric covalent binding as a means of attaining potency and selectivity for CDK7. Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state 1 , but direct pharmacological inhibition of transcription factors has so far proven difficult 2 . However, the transcriptional machinery contains various enzymatic cofactors that can be targeted for the development of new therapeutic candidates 3 , including cyclin-dependent kinases (CDKs) 4 . Here we present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukaemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide analysis in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumour cells. Pharmacological modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumour types that are dependent on transcription for maintenance of the oncogenic state.
Audience Academic
Author Sim, Taebo
Mitsiades, Constantine S.
Young, Richard A.
Weng, Andrew P.
Hannett, Nancy M.
Marto, Jarrod A.
Gray, Nathanael S.
Rahl, Peter B.
Kwiatkowski, Nicholas
Abraham, Brian J.
Ficarro, Scott B.
Brown, Jennifer R.
Sanda, Takaomi
Look, Thomas
McMillin, Douglas
Dastur, Anahita
Reddy, Jessica
Benes, Cyril H.
Amzallag, Arnaud
Ramaswamy, Sridhar
Jenkins, Catherine E.
Kim, Nam Doo
Zhang, Tinghu
Tesar, Bethany
AuthorAffiliation 4 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
7 Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
12 Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599
6 Department of Medicine Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
10 Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
18 Division of Hematology/Oncology, Children’s Hospital, Boston, MA 02115 USA
2 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
8 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
14 Daegu-Gyeongbuk Medical Innovation Foundation, 2387 dalgubeol-daero, Suseong-gu, Daegu, 706-010, Korea
3 Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
9 Department of Medicine, Brig
AuthorAffiliation_xml – name: 2 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
– name: 3 Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
– name: 10 Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
– name: 11 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
– name: 14 Daegu-Gyeongbuk Medical Innovation Foundation, 2387 dalgubeol-daero, Suseong-gu, Daegu, 706-010, Korea
– name: 7 Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
– name: 9 Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
– name: 12 Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599
– name: 5 Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA
– name: 8 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
– name: 13 Chemical Kinomics Research Center, Korea Institute of Science and Technology, 39-1, Hawolgok-dong, Seongbuk-gu, Seoul, 136-791, Korea/ KU-KIST Graduate School of Converging Science and Technology, 145, Anam-ro, Seoul, Korea
– name: 4 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
– name: 6 Department of Medicine Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
– name: 18 Division of Hematology/Oncology, Children’s Hospital, Boston, MA 02115 USA
– name: 1 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Author_xml – sequence: 1
  givenname: Nicholas
  surname: Kwiatkowski
  fullname: Kwiatkowski, Nicholas
  organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Whitehead Institute for Biomedical Research, 9 Cambridge Center
– sequence: 2
  givenname: Tinghu
  surname: Zhang
  fullname: Zhang, Tinghu
  organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
– sequence: 3
  givenname: Peter B.
  surname: Rahl
  fullname: Rahl, Peter B.
  organization: Whitehead Institute for Biomedical Research, 9 Cambridge Center
– sequence: 4
  givenname: Brian J.
  surname: Abraham
  fullname: Abraham, Brian J.
  organization: Whitehead Institute for Biomedical Research, 9 Cambridge Center
– sequence: 5
  givenname: Jessica
  surname: Reddy
  fullname: Reddy, Jessica
  organization: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Department of Biology, Massachusetts Institute of Technology
– sequence: 6
  givenname: Scott B.
  surname: Ficarro
  fullname: Ficarro, Scott B.
  organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blais Proteomics Center, Dana-Farber Cancer Institute
– sequence: 7
  givenname: Anahita
  surname: Dastur
  fullname: Dastur, Anahita
  organization: Department of Medicine Massachusetts General Hospital Cancer Center and Harvard Medical School
– sequence: 8
  givenname: Arnaud
  surname: Amzallag
  fullname: Amzallag, Arnaud
  organization: Department of Medicine Massachusetts General Hospital Cancer Center and Harvard Medical School, Broad Institute of MIT and Harvard, 7 Cambridge Center
– sequence: 9
  givenname: Sridhar
  surname: Ramaswamy
  fullname: Ramaswamy, Sridhar
  organization: Department of Medicine Massachusetts General Hospital Cancer Center and Harvard Medical School, Broad Institute of MIT and Harvard, 7 Cambridge Center
– sequence: 10
  givenname: Bethany
  surname: Tesar
  fullname: Tesar, Bethany
  organization: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
– sequence: 11
  givenname: Catherine E.
  surname: Jenkins
  fullname: Jenkins, Catherine E.
  organization: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
– sequence: 12
  givenname: Nancy M.
  surname: Hannett
  fullname: Hannett, Nancy M.
  organization: Whitehead Institute for Biomedical Research, 9 Cambridge Center
– sequence: 13
  givenname: Douglas
  surname: McMillin
  fullname: McMillin, Douglas
  organization: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
– sequence: 14
  givenname: Takaomi
  surname: Sanda
  fullname: Sanda, Takaomi
  organization: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Cancer Science Institute of Singapore, National University of Singapore, 117599 Singapore
– sequence: 15
  givenname: Taebo
  surname: Sim
  fullname: Sim, Taebo
  organization: Chemical Kinomics Research Center, Korea Institute of Science and Technology, 39-1, Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea, and KU-KIST Graduate School of Converging Science and Technology, 145, Anam-ro, Seongbuk-gu, Seoul 136-713, Korea
– sequence: 16
  givenname: Nam Doo
  surname: Kim
  fullname: Kim, Nam Doo
  organization: Daegu-Gyeongbuk Medical Innovation Foundation, 2387 dalgubeol-daero, Suseong-gu, Daegu 706-010, Korea
– sequence: 17
  givenname: Thomas
  surname: Look
  fullname: Look, Thomas
  organization: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Division of Hematology/Oncology, Children’s Hospital
– sequence: 18
  givenname: Constantine S.
  surname: Mitsiades
  fullname: Mitsiades, Constantine S.
  organization: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
– sequence: 19
  givenname: Andrew P.
  surname: Weng
  fullname: Weng, Andrew P.
  organization: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
– sequence: 20
  givenname: Jennifer R.
  surname: Brown
  fullname: Brown, Jennifer R.
  organization: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
– sequence: 21
  givenname: Cyril H.
  surname: Benes
  fullname: Benes, Cyril H.
  organization: Department of Medicine Massachusetts General Hospital Cancer Center and Harvard Medical School
– sequence: 22
  givenname: Jarrod A.
  surname: Marto
  fullname: Marto, Jarrod A.
  organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blais Proteomics Center, Dana-Farber Cancer Institute
– sequence: 23
  givenname: Richard A.
  surname: Young
  fullname: Young, Richard A.
  email: young@wi.mit.edu
  organization: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Department of Biology, Massachusetts Institute of Technology
– sequence: 24
  givenname: Nathanael S.
  surname: Gray
  fullname: Gray, Nathanael S.
  email: nathanael_gray@dfci.harvard.edu
  organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25043025$$D View this record in MEDLINE/PubMed
BookMark eNp1kttLHDEUh4Moum596nsZ2qdSxyaT67wIy1atKC3UhT6GTDYzG9lN1iRj2__e1Ft3YUogCTnf-eXcDsGu884A8BbBEwSx-OxU6oNBGNd4B4wQ4awkTPBdMIKwEiUUmB2AwxhvIYQUcbIPDioKCYYVHYGrmQqdSdZ1RQrKRR3sOlnvimC6fqker9YVWjltQvHLpkWhCu3v1dK4VEy_XPFsXtjGJh_egL1WLaM5ej7HYHZ-Npt-La-_X1xOJ9elZjVMJdeEUYYxaQzPGxRK1aTRmMA5JQJR3iChqa4QahVXbQ0RqVij5qjNqfAGj8Hpk-y6b1ZmrnMgQS3lOtiVCn-kV1ZuW5xdyM7fS1IRUueSjcGHZ4Hg73oTk7z1fXA5ZIkoRbVgFRP_qC7nKq1rfRbTKxu1nGDOakwIJZkqB6jOOJN_zn1qbX7e4t8P8Hpt7-QmdDIA5TU3K6sHVT9uOWQmmd-pU32M8vLmxzb76f_sZPZz-m2Q1sHHGEz7WmcE5d_xkxvjl-l3m615ZV_mLQPHT0DMJteZsFH6Ab0H2-Xi6g
CODEN NATUAS
CitedBy_id crossref_primary_10_1016_j_canlet_2022_215833
crossref_primary_10_1097_CAD_0000000000000749
crossref_primary_10_1158_2159_8290_CD_17_1211
crossref_primary_10_1038_s41698_017_0005_2
crossref_primary_10_3390_cancers16112130
crossref_primary_10_1016_j_molcel_2022_12_022
crossref_primary_10_2174_1568009623666230320144713
crossref_primary_10_1186_s12964_022_00837_z
crossref_primary_10_4155_fmc_2019_0334
crossref_primary_10_1517_13543776_2015_1045414
crossref_primary_10_1016_j_ccell_2020_12_003
crossref_primary_10_1016_j_bbcan_2022_188697
crossref_primary_10_1007_s00018_018_2820_1
crossref_primary_10_1016_j_molcel_2021_02_015
crossref_primary_10_1016_j_pathol_2018_10_004
crossref_primary_10_1016_j_xgen_2023_100276
crossref_primary_10_1002_cmdc_202200582
crossref_primary_10_1021_acschembio_2c00633
crossref_primary_10_3389_fonc_2017_00218
crossref_primary_10_1016_j_cell_2018_07_045
crossref_primary_10_1016_j_trecan_2015_07_001
crossref_primary_10_1021_jacs_1c13568
crossref_primary_10_1002_jcp_30011
crossref_primary_10_3390_cancers12082142
crossref_primary_10_3390_cells12131745
crossref_primary_10_1016_j_ccell_2017_12_002
crossref_primary_10_3390_cancers14184353
crossref_primary_10_1016_j_celrep_2020_107884
crossref_primary_10_1126_science_1259037
crossref_primary_10_2139_ssrn_3155601
crossref_primary_10_18632_oncotarget_22165
crossref_primary_10_1007_s11899_023_00706_7
crossref_primary_10_3390_cancers13112666
crossref_primary_10_1101_gad_348315_121
crossref_primary_10_1111_imr_12734
crossref_primary_10_1016_j_neuint_2020_104933
crossref_primary_10_1016_j_molcel_2017_01_012
crossref_primary_10_1021_acschembio_6b00267
crossref_primary_10_1172_JCI127718
crossref_primary_10_1016_j_pharmthera_2022_108229
crossref_primary_10_1126_scisignal_aam8216
crossref_primary_10_1146_annurev_biochem_060815_014857
crossref_primary_10_1016_j_xcrm_2024_101441
crossref_primary_10_1111_hepr_13353
crossref_primary_10_1126_sciadv_adk6633
crossref_primary_10_1016_j_exphem_2017_06_001
crossref_primary_10_1002_ame2_12032
crossref_primary_10_1158_2159_8290_CD_17_0461
crossref_primary_10_1016_j_pharmthera_2015_07_004
crossref_primary_10_1080_10428194_2023_2169045
crossref_primary_10_1182_blood_2017_03_775536
crossref_primary_10_1016_j_xpro_2023_102640
crossref_primary_10_1158_0008_5472_CAN_17_1904
crossref_primary_10_1016_j_ccell_2016_03_007
crossref_primary_10_1007_s10555_020_09885_8
crossref_primary_10_1002_ijc_32936
crossref_primary_10_3389_fonc_2023_1142111
crossref_primary_10_1111_cas_15232
crossref_primary_10_1093_nar_gkv1002
crossref_primary_10_1093_nar_gkv1243
crossref_primary_10_3390_ph14060589
crossref_primary_10_1097_BS9_0000000000000073
crossref_primary_10_1101_gad_244368_114
crossref_primary_10_1016_j_mtbio_2022_100286
crossref_primary_10_1016_j_chembiol_2015_08_018
crossref_primary_10_1007_s13402_019_00434_2
crossref_primary_10_3389_fphar_2019_00361
crossref_primary_10_3390_metabo13101064
crossref_primary_10_1016_j_trecan_2017_03_006
crossref_primary_10_1364_OE_23_031956
crossref_primary_10_1007_s12032_023_01997_9
crossref_primary_10_1038_s41388_019_0701_1
crossref_primary_10_1186_s13046_023_02763_5
crossref_primary_10_3390_cancers12061361
crossref_primary_10_1016_j_cbpa_2021_02_002
crossref_primary_10_1038_s41556_020_00578_6
crossref_primary_10_1080_13543784_2016_1234603
crossref_primary_10_3390_cancers14184375
crossref_primary_10_1093_nar_gkad908
crossref_primary_10_1016_j_drudis_2020_09_035
crossref_primary_10_1186_s12906_019_2590_9
crossref_primary_10_1021_acschembio_6b00043
crossref_primary_10_1080_21541264_2018_1553483
crossref_primary_10_1101_gr_266924_120
crossref_primary_10_1038_s41408_021_00421_7
crossref_primary_10_1038_s41467_023_38132_1
crossref_primary_10_1172_jci_insight_122225
crossref_primary_10_1124_mol_114_095489
crossref_primary_10_1016_j_ccell_2021_07_021
crossref_primary_10_18632_oncotarget_26579
crossref_primary_10_1016_j_ejmech_2017_04_003
crossref_primary_10_1038_s41467_019_09703_y
crossref_primary_10_1016_j_jbc_2023_103064
crossref_primary_10_1002_cmdc_202300281
crossref_primary_10_1016_j_pharmthera_2020_107722
crossref_primary_10_1002_cam4_4483
crossref_primary_10_1016_j_cell_2016_12_013
crossref_primary_10_3389_fonc_2017_00241
crossref_primary_10_1016_j_it_2021_03_005
crossref_primary_10_1016_j_jmb_2016_02_006
crossref_primary_10_1186_s12964_023_01468_8
crossref_primary_10_1242_dmm_041988
crossref_primary_10_3389_fphar_2024_1383580
crossref_primary_10_1073_pnas_1815780116
crossref_primary_10_1016_j_gene_2021_145421
crossref_primary_10_1021_acs_jmedchem_3c01832
crossref_primary_10_1126_scitranslmed_abb2233
crossref_primary_10_1158_0008_5472_CAN_23_0650
crossref_primary_10_1080_13543776_2023_2195547
crossref_primary_10_1016_j_celrep_2023_112979
crossref_primary_10_1016_j_tem_2018_02_005
crossref_primary_10_1021_acs_jmedchem_6b01815
crossref_primary_10_1038_s41467_024_46375_9
crossref_primary_10_1158_0008_5472_CAN_21_4222
crossref_primary_10_1007_s10555_015_9601_1
crossref_primary_10_1016_j_csbj_2021_05_006
crossref_primary_10_1021_acs_jmedchem_0c00766
crossref_primary_10_1016_j_phrs_2017_11_015
crossref_primary_10_1093_nar_gkad609
crossref_primary_10_1016_j_cell_2015_09_013
crossref_primary_10_3390_cancers13081801
crossref_primary_10_3390_cells12081191
crossref_primary_10_3390_cells11091560
crossref_primary_10_1111_febs_17136
crossref_primary_10_1038_s41467_020_14604_6
crossref_primary_10_3390_ijms21082974
crossref_primary_10_1016_j_chembiol_2015_07_018
crossref_primary_10_1038_s41401_018_0187_3
crossref_primary_10_1126_science_aaa3247
crossref_primary_10_1158_1535_7163_MCT_16_0847
crossref_primary_10_7554_eLife_23268
crossref_primary_10_1038_s41375_023_02000_0
crossref_primary_10_1016_j_molcel_2018_02_011
crossref_primary_10_1111_jcmm_14841
crossref_primary_10_3390_cancers12082137
crossref_primary_10_1007_s13402_021_00608_x
crossref_primary_10_1016_j_cbpa_2015_11_004
crossref_primary_10_3389_fimmu_2022_849451
crossref_primary_10_1016_j_ccell_2017_12_009
crossref_primary_10_3390_cancers14071690
crossref_primary_10_1016_j_chembiol_2017_11_007
crossref_primary_10_1093_nar_gkw085
crossref_primary_10_1182_blood_2019002639
crossref_primary_10_1038_srep20441
crossref_primary_10_1124_pharmrev_122_000795
crossref_primary_10_3390_cells11020279
crossref_primary_10_1002_lio2_22
crossref_primary_10_1126_sciadv_adj0123
crossref_primary_10_1136_gutjnl_2016_311818
crossref_primary_10_1016_j_ejmech_2024_116613
crossref_primary_10_3389_fnmol_2017_00365
crossref_primary_10_1158_2159_8290_CD_17_1245
crossref_primary_10_7554_eLife_75475
crossref_primary_10_1016_j_ccell_2019_09_004
crossref_primary_10_3390_cancers13246251
crossref_primary_10_12688_f1000research_7879_1
crossref_primary_10_1002_cmdc_201600535
crossref_primary_10_1016_j_crchbi_2022_100040
crossref_primary_10_1016_j_celrep_2019_05_043
crossref_primary_10_1093_nar_gkz127
crossref_primary_10_3390_biomedicines12030679
crossref_primary_10_1038_s41418_022_00953_w
crossref_primary_10_1074_jbc_M116_751420
crossref_primary_10_1080_14656566_2020_1738385
crossref_primary_10_1038_s41413_018_0009_8
crossref_primary_10_1186_s13046_023_02750_w
crossref_primary_10_1021_acs_jmedchem_7b00901
crossref_primary_10_1002_iub_2574
crossref_primary_10_1080_15548627_2020_1763019
crossref_primary_10_1097_BS9_0000000000000009
crossref_primary_10_3390_molecules28031141
crossref_primary_10_1182_blood_2023020144
crossref_primary_10_1038_s41392_018_0008_7
crossref_primary_10_1016_j_pharmthera_2017_02_008
crossref_primary_10_1182_blood_2017_11_737379
crossref_primary_10_1038_s41586_023_06341_9
crossref_primary_10_3390_cancers14071714
crossref_primary_10_1016_j_molcel_2018_08_023
crossref_primary_10_1158_1535_7163_MCT_17_0078
crossref_primary_10_1039_C6RA27740C
crossref_primary_10_1016_j_tig_2018_11_007
crossref_primary_10_1016_j_chembiol_2019_02_021
crossref_primary_10_1038_nchembio_2458
crossref_primary_10_1016_j_ejmech_2021_113309
crossref_primary_10_1126_scitranslmed_abo6891
crossref_primary_10_1016_j_exphem_2015_12_001
crossref_primary_10_1021_acs_analchem_1c02349
crossref_primary_10_3390_cancers11050634
crossref_primary_10_1038_s41467_019_12656_x
crossref_primary_10_1182_blood_2018893982
crossref_primary_10_1016_j_bbamcr_2016_09_020
crossref_primary_10_1016_j_bmcl_2019_126637
crossref_primary_10_1016_j_drudis_2018_01_035
crossref_primary_10_1038_s41568_019_0196_7
crossref_primary_10_1038_s41568_021_00411_8
crossref_primary_10_1007_s00405_019_05757_2
crossref_primary_10_1038_s41375_020_0981_z
crossref_primary_10_3923_ijcr_2016_109_121
crossref_primary_10_1016_j_canlet_2024_216882
crossref_primary_10_1084_jem_20190251
crossref_primary_10_1016_j_cell_2015_08_063
crossref_primary_10_1111_odi_13783
crossref_primary_10_1007_s41061_017_0117_8
crossref_primary_10_1038_s41591_018_0312_3
crossref_primary_10_1111_febs_16089
crossref_primary_10_1016_j_bbagrm_2024_195024
crossref_primary_10_1039_C9CS00720B
crossref_primary_10_3324_haematol_2022_280761
crossref_primary_10_1158_0008_5472_CAN_18_3215
crossref_primary_10_1016_j_gendis_2022_01_006
crossref_primary_10_1016_j_cbpa_2022_102186
crossref_primary_10_1038_s41467_023_38952_1
crossref_primary_10_1021_jacs_0c02721
crossref_primary_10_1016_j_celrep_2015_12_025
crossref_primary_10_1016_j_molcel_2015_06_032
crossref_primary_10_1186_s12964_022_00928_x
crossref_primary_10_1016_j_canlet_2021_03_012
crossref_primary_10_1038_s41570_024_00593_3
crossref_primary_10_3390_md18070350
crossref_primary_10_7554_eLife_59770
crossref_primary_10_1038_s41467_019_13334_8
crossref_primary_10_1016_j_cell_2014_10_024
crossref_primary_10_1093_nar_gkz272
crossref_primary_10_1016_j_chembiol_2020_02_003
crossref_primary_10_1038_ncomms14385
crossref_primary_10_1038_s41467_019_11132_w
crossref_primary_10_1016_j_bbrc_2019_10_052
crossref_primary_10_1093_cvr_cvae084
crossref_primary_10_1080_21541264_2016_1268244
crossref_primary_10_1016_j_molcel_2022_05_010
crossref_primary_10_1016_j_chembiol_2020_10_001
crossref_primary_10_1038_s41556_018_0086_3
crossref_primary_10_3390_diagnostics14101028
crossref_primary_10_2217_ijh_14_44
crossref_primary_10_1038_s41573_022_00409_3
crossref_primary_10_1021_acs_analchem_6b03394
crossref_primary_10_1038_s41586_019_1517_4
crossref_primary_10_1016_j_molcel_2017_06_004
crossref_primary_10_1007_s40610_019_00125_9
crossref_primary_10_1038_s41419_021_04050_7
crossref_primary_10_1038_s41467_023_37049_z
crossref_primary_10_1126_sciadv_abm5504
crossref_primary_10_1002_med_21856
crossref_primary_10_1007_s12185_018_2518_z
crossref_primary_10_1016_j_xcrm_2023_101007
crossref_primary_10_1016_j_ejmech_2020_113137
crossref_primary_10_2147_OTT_S366627
crossref_primary_10_18632_oncotarget_19761
crossref_primary_10_1038_s41388_022_02210_3
crossref_primary_10_1186_s12964_024_01577_y
crossref_primary_10_15252_emmm_201911099
crossref_primary_10_1186_s12964_024_01599_6
crossref_primary_10_4155_fmc_2017_0246
crossref_primary_10_1158_1078_0432_CCR_15_1104
crossref_primary_10_1096_fj_202400769R
crossref_primary_10_1016_j_molcel_2019_02_031
crossref_primary_10_1016_j_chembiol_2018_01_013
crossref_primary_10_1073_pnas_2010885117
crossref_primary_10_1146_annurev_cancerbio_040716_075628
crossref_primary_10_2174_1573406417666210806095710
crossref_primary_10_3390_ijms21093354
crossref_primary_10_1073_pnas_1804663115
crossref_primary_10_1016_j_celrep_2017_07_021
crossref_primary_10_1158_1078_0432_CCR_19_1418
crossref_primary_10_1016_j_cell_2018_03_053
crossref_primary_10_3390_ijms25116123
crossref_primary_10_1016_j_chest_2020_04_068
crossref_primary_10_1016_j_coviro_2017_08_004
crossref_primary_10_18632_aging_202595
crossref_primary_10_1038_s41589_022_01046_y
crossref_primary_10_1182_blood_2017_06_792184
crossref_primary_10_1021_acsmedchemlett_7b00008
crossref_primary_10_1038_ncomms14290
crossref_primary_10_1186_s13046_022_02428_9
crossref_primary_10_3389_fcell_2020_00534
crossref_primary_10_1111_php_13164
crossref_primary_10_3390_ncrna10010005
crossref_primary_10_1038_s41467_022_31329_w
crossref_primary_10_1016_j_mrrev_2024_108489
crossref_primary_10_1186_s13045_019_0757_y
crossref_primary_10_1002_anie_201707875
crossref_primary_10_1016_j_ejmech_2016_01_011
crossref_primary_10_3390_cancers14020293
crossref_primary_10_1080_13543784_2023_2288075
crossref_primary_10_1126_sciadv_abf6123
crossref_primary_10_1093_jmcb_mjad044
crossref_primary_10_1016_j_cbpa_2017_06_015
crossref_primary_10_1126_science_aar3958
crossref_primary_10_1016_j_ccell_2017_03_011
crossref_primary_10_3390_ijms20122883
crossref_primary_10_1038_s41422_018_0020_z
crossref_primary_10_1186_s12943_022_01701_x
crossref_primary_10_1158_2326_6066_CIR_20_0405
crossref_primary_10_1016_j_molcel_2016_06_036
crossref_primary_10_1080_13543784_2021_1850693
crossref_primary_10_1186_s13072_017_0135_3
crossref_primary_10_3390_cancers14235971
crossref_primary_10_1016_j_ejmech_2023_116014
crossref_primary_10_1038_s41375_018_0110_4
crossref_primary_10_1016_j_gene_2020_145200
crossref_primary_10_3390_cells10051182
crossref_primary_10_1016_j_celrep_2017_09_056
crossref_primary_10_3389_fonc_2020_01628
crossref_primary_10_1038_nrm_2017_113
crossref_primary_10_1016_j_antiviral_2016_12_017
crossref_primary_10_1016_j_msec_2019_110460
crossref_primary_10_1016_j_coph_2021_04_001
crossref_primary_10_1158_2159_8290_CD_19_0189
crossref_primary_10_1371_journal_pone_0163649
crossref_primary_10_1002_ctm2_1500
crossref_primary_10_1016_j_ccell_2018_11_001
crossref_primary_10_1111_imr_12237
crossref_primary_10_1038_s41375_024_02331_6
crossref_primary_10_1038_s41598_019_43760_z
crossref_primary_10_1038_s41698_020_00137_0
crossref_primary_10_1101_gad_324202_119
crossref_primary_10_4155_fmc_2020_0240
crossref_primary_10_1158_1535_7163_MCT_21_0891
crossref_primary_10_1016_j_chembiol_2019_02_012
crossref_primary_10_1093_nar_gkad792
crossref_primary_10_1016_j_bbrc_2016_08_109
crossref_primary_10_1016_j_isci_2023_106795
crossref_primary_10_1002_med_21676
crossref_primary_10_1002_cmdc_201900107
crossref_primary_10_1021_acs_jcim_3c00014
crossref_primary_10_1016_j_tig_2022_06_006
crossref_primary_10_1038_onc_2014_305
crossref_primary_10_1016_j_mcpro_2024_100802
crossref_primary_10_1016_j_molcel_2023_10_017
crossref_primary_10_1038_s41418_018_0222_4
crossref_primary_10_1098_rsob_200121
crossref_primary_10_1002_dvg_23422
crossref_primary_10_1186_s13046_018_0704_8
crossref_primary_10_18632_oncotarget_10870
crossref_primary_10_1158_0008_5472_CAN_17_1494
crossref_primary_10_1016_j_ccell_2019_04_005
crossref_primary_10_1038_s41375_022_01758_z
crossref_primary_10_18632_oncotarget_16040
crossref_primary_10_1021_jacs_8b07911
crossref_primary_10_1016_j_biopha_2023_114492
crossref_primary_10_1038_nchembio_2166
crossref_primary_10_1074_jbc_M117_788406
crossref_primary_10_15252_embj_2019102566
crossref_primary_10_1039_D2MD00291D
crossref_primary_10_3390_microorganisms8091262
crossref_primary_10_1038_nrd4504
crossref_primary_10_1016_j_canlet_2019_12_005
crossref_primary_10_1038_s41467_022_34179_8
crossref_primary_10_1016_j_ejphar_2021_174298
crossref_primary_10_1080_10428194_2017_1410882
crossref_primary_10_3166_onco_2018_0011
crossref_primary_10_1038_s41388_018_0661_x
crossref_primary_10_1038_s41416_024_02589_8
crossref_primary_10_1186_s13046_023_02790_2
crossref_primary_10_1038_onc_2016_382
crossref_primary_10_1093_nar_gkad258
crossref_primary_10_1021_acs_jmedchem_6b01055
crossref_primary_10_1080_21541264_2018_1535211
crossref_primary_10_1074_jbc_RA117_001347
crossref_primary_10_1182_blood_2019004586
crossref_primary_10_1186_s13008_017_0033_x
crossref_primary_10_1002_glia_24186
crossref_primary_10_3390_cells9030638
crossref_primary_10_1016_j_cbpa_2017_05_008
crossref_primary_10_1038_s41467_023_41340_4
crossref_primary_10_1038_onc_2015_360
crossref_primary_10_1371_journal_pone_0276467
crossref_primary_10_1042_EBC20170040
crossref_primary_10_1016_j_jbc_2023_105501
crossref_primary_10_1021_acs_jmedchem_9b01929
crossref_primary_10_1038_ng_3167
crossref_primary_10_1038_nature14904
crossref_primary_10_1016_j_crmeth_2023_100674
crossref_primary_10_1016_j_ejmech_2022_114433
crossref_primary_10_1038_s41419_023_05966_y
crossref_primary_10_1073_pnas_2009627117
crossref_primary_10_3389_fphar_2023_1192855
crossref_primary_10_1021_acs_jmedchem_2c01334
crossref_primary_10_1038_s41580_022_00498_3
crossref_primary_10_3390_cells9030621
crossref_primary_10_1093_hmg_ddaa218
crossref_primary_10_1158_1535_7163_MCT_20_0489
crossref_primary_10_3389_fonc_2021_663360
crossref_primary_10_18632_oncotarget_12701
crossref_primary_10_1016_j_isci_2020_101163
crossref_primary_10_3390_ijms24087009
crossref_primary_10_3390_ijms23020812
crossref_primary_10_3390_molecules27227728
crossref_primary_10_1007_s00018_021_03878_8
crossref_primary_10_1016_j_bbcan_2021_188620
crossref_primary_10_1002_advs_201902926
crossref_primary_10_1021_jacs_6b05483
crossref_primary_10_3390_cancers14030492
crossref_primary_10_1038_nrd_2018_21
crossref_primary_10_3389_fimmu_2020_592087
crossref_primary_10_1002_jcb_27292
crossref_primary_10_1038_s41467_020_16559_0
crossref_primary_10_1038_s41588_020_0602_9
crossref_primary_10_1016_j_cell_2017_02_015
crossref_primary_10_3390_cancers14143452
crossref_primary_10_1093_nar_gky1207
crossref_primary_10_1038_leu_2016_82
crossref_primary_10_1016_j_exphem_2015_05_017
crossref_primary_10_1038_s41467_021_23417_0
crossref_primary_10_1080_13543784_2023_2161361
crossref_primary_10_1158_1078_0432_CCR_18_3788
crossref_primary_10_1038_s41388_020_1284_6
crossref_primary_10_15252_emmm_202114990
crossref_primary_10_1038_nrc_2016_63
crossref_primary_10_1016_j_jbc_2023_104834
crossref_primary_10_1590_1678_4685_gmb_2022_0313
crossref_primary_10_3390_ijms22062806
crossref_primary_10_1016_j_cell_2021_04_022
crossref_primary_10_1038_s41389_020_00285_9
crossref_primary_10_1002_cmdc_201500469
crossref_primary_10_1016_j_ccell_2019_11_003
crossref_primary_10_1093_jb_mvab032
crossref_primary_10_1016_j_cell_2017_02_007
crossref_primary_10_1039_D3MD00004D
crossref_primary_10_1124_mol_115_099325
crossref_primary_10_1038_s41592_020_0801_4
crossref_primary_10_1182_blood_2016_12_754051
crossref_primary_10_1080_21541264_2018_1539615
crossref_primary_10_1093_nar_gkx1225
crossref_primary_10_1038_s41589_020_0563_4
crossref_primary_10_1038_s41571_021_00549_2
crossref_primary_10_1016_j_molimm_2021_05_004
crossref_primary_10_1002_advs_202101895
crossref_primary_10_1146_annurev_biochem_061516_044805
crossref_primary_10_1038_leu_2017_75
crossref_primary_10_1016_j_ebiom_2016_04_032
crossref_primary_10_1021_acs_jmedchem_1c01951
crossref_primary_10_1016_j_celrep_2020_108469
crossref_primary_10_1101_gad_341545_120
crossref_primary_10_1038_s41388_022_02347_1
crossref_primary_10_1021_acs_jmedchem_1c01719
crossref_primary_10_15252_embj_201591206
crossref_primary_10_3892_ol_2020_11855
crossref_primary_10_1038_s41419_022_04673_4
crossref_primary_10_1038_s41573_021_00199_0
crossref_primary_10_1158_2643_3230_BCD_20_0108
crossref_primary_10_1016_j_ccell_2014_11_012
crossref_primary_10_1016_j_bbcan_2020_188353
crossref_primary_10_3390_ijms21020630
crossref_primary_10_3390_molecules26196074
crossref_primary_10_1074_jbc_M115_696039
crossref_primary_10_1016_j_cdtm_2019_08_006
crossref_primary_10_3390_cancers14122866
crossref_primary_10_1091_mbc_E23_01_0004
crossref_primary_10_1093_nar_gkz1038
crossref_primary_10_1016_j_cellsig_2017_10_007
crossref_primary_10_1016_j_ejmech_2021_113481
crossref_primary_10_1371_journal_ppat_1012138
crossref_primary_10_1093_nar_gky1233
crossref_primary_10_1002_ijc_32069
crossref_primary_10_1158_0008_5472_CAN_16_2546
crossref_primary_10_3389_fgene_2021_673530
crossref_primary_10_1182_bloodadvances_2021004469
crossref_primary_10_1080_13543784_2022_2097067
crossref_primary_10_26508_lsa_202201854
crossref_primary_10_3389_fcell_2017_00010
crossref_primary_10_1016_j_ccell_2021_03_010
crossref_primary_10_1093_carcin_bgac036
crossref_primary_10_1098_rsob_200050
crossref_primary_10_1158_1535_7163_MCT_16_0172
crossref_primary_10_1016_j_ejmech_2015_12_023
crossref_primary_10_1038_s41388_022_02446_z
crossref_primary_10_1158_1535_7163_MCT_16_0050
crossref_primary_10_1038_s41580_018_0010_5
crossref_primary_10_1101_gr_197590_115
crossref_primary_10_1016_j_celrep_2023_113363
crossref_primary_10_1016_j_canlet_2014_11_048
crossref_primary_10_1089_thy_2018_0550
crossref_primary_10_1016_j_cell_2017_07_033
crossref_primary_10_1016_j_celrep_2021_109013
crossref_primary_10_1038_s41389_020_0232_1
crossref_primary_10_1083_jcb_202008146
crossref_primary_10_1186_s12964_019_0440_5
crossref_primary_10_1021_acs_jmedchem_1c01171
crossref_primary_10_1186_s13072_023_00502_w
crossref_primary_10_1186_s13045_020_00926_x
crossref_primary_10_7554_eLife_39030
crossref_primary_10_1126_scitranslmed_abn9674
crossref_primary_10_1021_acs_jmedchem_9b01985
crossref_primary_10_1002_ange_201707875
crossref_primary_10_1016_j_ejmech_2019_111641
crossref_primary_10_1016_j_celrep_2022_111979
crossref_primary_10_1128_JVI_01390_20
crossref_primary_10_1158_0008_5472_CAN_22_0222
crossref_primary_10_1002_1873_3468_14335
crossref_primary_10_1101_gad_310367_117
crossref_primary_10_1016_j_celrep_2022_110400
crossref_primary_10_1038_s41375_022_01655_5
crossref_primary_10_1038_s43018_020_00114_3
crossref_primary_10_1158_2159_8290_CD_19_0528
crossref_primary_10_1126_science_aaz4427
crossref_primary_10_1111_bjh_17310
crossref_primary_10_1016_j_ejmech_2017_08_071
crossref_primary_10_1016_j_tibs_2022_01_002
crossref_primary_10_1186_s12920_021_01064_0
crossref_primary_10_1038_oncsis_2017_33
crossref_primary_10_1016_j_tranon_2023_101729
crossref_primary_10_1038_onc_2015_85
crossref_primary_10_1186_s12943_020_01301_7
crossref_primary_10_1016_S1286_935X_21_44904_X
crossref_primary_10_1038_s41420_023_01754_x
crossref_primary_10_1158_2159_8290_CD_17_0860
crossref_primary_10_1038_leu_2016_392
crossref_primary_10_1158_1078_0432_CCR_23_2975
crossref_primary_10_1016_j_ccell_2018_01_004
crossref_primary_10_1016_j_tig_2022_05_015
crossref_primary_10_1002_pro_3424
crossref_primary_10_1038_s41388_019_1008_y
crossref_primary_10_1101_gad_277178_115
crossref_primary_10_1146_annurev_cancerbio_030518_055826
crossref_primary_10_1093_carcin_bgae006
crossref_primary_10_1016_j_ejphar_2023_175892
crossref_primary_10_3389_fcell_2021_631486
crossref_primary_10_1016_j_bbamcr_2019_03_002
crossref_primary_10_1016_j_xcrm_2020_100188
crossref_primary_10_1038_s12276_020_0428_7
crossref_primary_10_3390_cells11020196
crossref_primary_10_18632_oncotarget_11583
crossref_primary_10_3389_fonc_2021_664848
crossref_primary_10_1128_MCB_00602_18
crossref_primary_10_1158_2159_8290_CD_17_0993
crossref_primary_10_1016_j_ejmech_2023_115648
crossref_primary_10_1038_s41467_019_13515_5
crossref_primary_10_3390_cancers13061235
crossref_primary_10_1146_annurev_cancerbio_030518_055710
crossref_primary_10_15252_embr_202051683
crossref_primary_10_1038_s41388_021_01793_7
crossref_primary_10_1158_2159_8290_CD_20_1848
crossref_primary_10_1016_j_ymthe_2022_01_038
crossref_primary_10_1038_srep37581
crossref_primary_10_1016_j_bioorg_2024_107456
crossref_primary_10_1016_j_yexcr_2020_112215
crossref_primary_10_1016_j_ygyno_2019_11_004
crossref_primary_10_3390_cells11244124
crossref_primary_10_3390_molecules23051057
crossref_primary_10_1016_j_str_2024_05_011
crossref_primary_10_1101_gad_333146_119
crossref_primary_10_3390_cancers14246178
crossref_primary_10_1021_acscentsci_3c01245
crossref_primary_10_1021_acs_jmedchem_1c02064
crossref_primary_10_1126_scitranslmed_abh3462
crossref_primary_10_1158_2643_3230_BCD_20_0093
crossref_primary_10_1021_acsnano_1c04570
crossref_primary_10_3390_cells9061483
crossref_primary_10_1038_s41587_020_00778_3
crossref_primary_10_1038_srep35288
crossref_primary_10_1158_2159_8290_CD_19_0970
crossref_primary_10_1007_s00418_024_02293_x
crossref_primary_10_1093_neuonc_noad143
crossref_primary_10_1016_j_ccell_2014_10_019
crossref_primary_10_1158_0008_5472_CAN_21_0921
crossref_primary_10_1093_bib_bbad107
crossref_primary_10_3389_fonc_2021_773186
crossref_primary_10_1021_jacs_9b09684
crossref_primary_10_1126_sciadv_abn0238
crossref_primary_10_1186_s13046_021_01941_7
crossref_primary_10_1038_nrc3877
crossref_primary_10_1038_s41419_021_04027_6
crossref_primary_10_1016_j_str_2024_03_003
crossref_primary_10_1080_21541264_2017_1331723
crossref_primary_10_3390_cells8111469
crossref_primary_10_1155_2022_7912484
crossref_primary_10_1016_j_molmed_2019_09_011
crossref_primary_10_1038_s41467_021_24168_8
crossref_primary_10_1172_JCI76094
crossref_primary_10_1073_pnas_1717920115
crossref_primary_10_1016_j_bmcl_2015_05_100
crossref_primary_10_1016_j_heliyon_2024_e24389
crossref_primary_10_1371_journal_pgen_1006262
crossref_primary_10_1039_D2MD00216G
crossref_primary_10_1002_hep_30544
crossref_primary_10_1038_s41388_020_01459_w
crossref_primary_10_3390_ijms25063103
crossref_primary_10_3389_fonc_2023_1152087
crossref_primary_10_3390_biomedicines9091197
crossref_primary_10_1016_j_jid_2017_09_056
crossref_primary_10_1038_s41556_024_01394_y
crossref_primary_10_1016_j_ejmech_2023_115955
crossref_primary_10_1016_j_molcel_2024_05_007
crossref_primary_10_1038_s41467_018_05923_w
crossref_primary_10_1126_science_abn7625
crossref_primary_10_1016_j_critrevonc_2019_01_009
crossref_primary_10_3389_fmolb_2021_697457
crossref_primary_10_1038_s41467_022_31541_8
crossref_primary_10_1016_j_celrep_2017_03_015
crossref_primary_10_1158_0008_5472_CAN_19_0119
crossref_primary_10_7554_eLife_07777
crossref_primary_10_1038_s41588_018_0191_z
crossref_primary_10_1038_gene_2016_25
crossref_primary_10_1038_s41467_023_40061_y
crossref_primary_10_1038_nsmb_3233
crossref_primary_10_1002_tox_23907
crossref_primary_10_18632_oncotarget_16957
crossref_primary_10_1038_s41388_019_0953_9
crossref_primary_10_2139_ssrn_3155590
crossref_primary_10_3390_molecules26237069
crossref_primary_10_1002_hep_31761
crossref_primary_10_1021_acs_jmedchem_6b00788
crossref_primary_10_1038_nchembio_2184
crossref_primary_10_1038_s41419_019_1831_7
crossref_primary_10_1016_j_ejmech_2021_114056
crossref_primary_10_1007_s12032_023_02005_w
crossref_primary_10_1016_j_molcel_2015_08_006
crossref_primary_10_1016_j_ejmech_2019_01_003
crossref_primary_10_1038_s41573_019_0044_1
crossref_primary_10_1016_j_pharmthera_2019_02_014
crossref_primary_10_1038_s41416_023_02252_8
crossref_primary_10_7554_eLife_20722
crossref_primary_10_1016_j_bbcan_2022_188680
crossref_primary_10_3390_ijms22147340
crossref_primary_10_1038_s41467_019_10131_1
crossref_primary_10_1158_0008_5472_CAN_17_1143
crossref_primary_10_1002_1878_0261_13319
crossref_primary_10_1073_pnas_1612745113
crossref_primary_10_1158_0008_5472_CAN_20_2245
Cites_doi 10.1021/bi062142x
10.4161/trns.25146
10.1016/j.cell.2010.03.030
10.1016/j.cell.2013.03.036
10.1038/nsmb.2399
10.1091/mbc.3.1.13
10.1016/j.ccr.2013.11.003
10.1101/gad.232710.113
10.1016/0092-8674(94)90535-5
10.1016/j.cell.2013.09.053
10.1038/371254a0
10.1038/374283a0
10.1016/j.molcel.2005.11.024
10.1038/374280a0
10.1128/MCB.00637-09
10.1016/j.molcel.2009.04.016
10.1016/j.molcel.2007.02.003
10.1177/1087057112437763
10.1016/j.ccr.2012.06.007
10.1182/blood-2007-07-100883
10.1046/j.1365-2443.2000.00336.x
10.1101/gad.1968210
10.1016/0092-8674(94)90040-X
10.1038/sj.onc.1210766
10.1093/nar/gkn923
10.1016/j.cell.2012.10.012
10.1073/pnas.93.13.6488
10.1016/j.cbpa.2008.07.023
10.1038/nature11005
10.1016/j.molcel.2013.04.003
ContentType Journal Article
Copyright Springer Nature Limited 2014
COPYRIGHT 2014 Nature Publishing Group
Copyright Nature Publishing Group Jul 31, 2014
Copyright_xml – notice: Springer Nature Limited 2014
– notice: COPYRIGHT 2014 Nature Publishing Group
– notice: Copyright Nature Publishing Group Jul 31, 2014
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
ATWCN
3V.
7QG
7QL
7QP
7QR
7RV
7SN
7SS
7ST
7T5
7TG
7TK
7TM
7TO
7U9
7X2
7X7
7XB
88A
88E
88G
88I
8AF
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
8G5
ABJCF
ABUWG
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BEC
BENPR
BGLVJ
BHPHI
BKSAR
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M2M
M2O
M2P
M7N
M7P
M7S
MBDVC
NAPCQ
P5Z
P62
P64
PATMY
PCBAR
PDBOC
PQEST
PQQKQ
PQUKI
PSYQQ
PTHSS
PYCSY
Q9U
R05
RC3
S0X
SOI
5PM
DOI 10.1038/nature13393
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Gale In Context: Middle School
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
ProQuest - Health & Medical Complete保健、医学与药学数据库
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
Science Database (Alumni Edition)
STEM Database
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest Central
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
eLibrary
ProQuest Central
Technology Collection
Natural Science Collection
Earth, Atmospheric & Aquatic Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agriculture Science Database
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Psychology Database
ProQuest research library
Science Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Research Library (Corporate)
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Earth, Atmospheric & Aquatic Science Database
Materials Science Collection
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest One Psychology
Engineering Collection
Environmental Science Collection
ProQuest Central Basic
University of Michigan
Genetics Abstracts
SIRS Editorial
Environment Abstracts
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Agricultural Science Database
ProQuest One Psychology
Research Library Prep
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
elibrary
ProQuest AP Science
SciTech Premium Collection
Environmental Sciences and Pollution Management
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Earth, Atmospheric & Aquatic Science Database
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Meteorological & Geoastrophysical Abstracts - Academic
University of Michigan
Technology Collection
Technology Research Database
SIRS Editorial
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Earth, Atmospheric & Aquatic Science Collection
Genetics Abstracts
ProQuest Engineering Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Research Library
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Central Basic
ProQuest Science Journals
ProQuest Nursing & Allied Health Source
ProQuest Psychology Journals (Alumni)
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
ProQuest Psychology Journals
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
DatabaseTitleList

MEDLINE
Agricultural Science Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Physics
EISSN 1476-4687
EndPage 620
ExternalDocumentID 3396333311
A376934454
10_1038_nature13393
25043025
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NHGRI NIH HHS
  grantid: U54 HG006097
– fundername: NCI NIH HHS
  grantid: CA109901
– fundername: NIGMS NIH HHS
  grantid: T32 GM008042
– fundername: NCI NIH HHS
  grantid: R01 CA130876
– fundername: NHGRI NIH HHS
  grantid: R01 HG002668
– fundername: NCI NIH HHS
  grantid: R21 CA178860
– fundername: NCI NIH HHS
  grantid: R01 CA179483
– fundername: NCI NIH HHS
  grantid: R01 CA130876-04
– fundername: NHGRI NIH HHS
  grantid: HG002668
– fundername: NINDS NIH HHS
  grantid: P01 NS047572-10
GroupedDBID ---
--Z
-DZ
-ET
-~X
.55
.CO
.XZ
00M
07C
0R~
0WA
123
186
1OL
1VR
29M
2KS
2XV
39C
3V.
4.4
41X
53G
5RE
6TJ
70F
7RV
7X2
7X7
7XC
85S
88A
88E
88I
8AF
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
8G5
8R4
8R5
8WZ
97F
97L
A6W
A7Z
A8Z
AAEEF
AAHBH
AAHTB
AAIKC
AAKAB
AAKAS
AAMNW
AASDW
AAYEP
AAZLF
ABAWZ
ABDBF
ABFSI
ABIVO
ABJCF
ABJNI
ABLJU
ABOCM
ABPEJ
ABPPZ
ABUWG
ABVXF
ABWJO
ABZEH
ACBEA
ACBWK
ACGFO
ACGFS
ACGOD
ACIWK
ACKOT
ACMJI
ACNCT
ACPRK
ACWUS
ADBBV
ADFRT
ADUKH
ADYSU
ADZCM
AENEX
AFFNX
AFKRA
AFLOW
AFRAH
AFRQD
AFSHS
AGAYW
AGEZK
AGHSJ
AGHTU
AGNAY
AGSOS
AHMBA
AHSBF
AIDAL
AIDUJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
APEBS
ARAPS
ARMCB
ARTTT
ASPBG
ATCPS
ATWCN
AVWKF
AXYYD
AZFZN
AZQEC
B-7
B0M
BBNVY
BCU
BDKGC
BEC
BENPR
BGLVJ
BHPHI
BIN
BKEYQ
BKKNO
BKSAR
BLC
BPHCQ
BVXVI
CCPQU
CJ0
CS3
D1I
D1J
D1K
DO4
DU5
DWQXO
E.-
E.L
EAD
EAP
EAS
EAZ
EBC
EBD
EBO
EBS
ECC
EE.
EJD
EMB
EMF
EMH
EMK
EMOBN
EPL
EPS
ESE
ESN
ESTFP
ESX
EX3
EXGXG
F20
F5P
FEDTE
FQGFK
FSGXE
FYUFA
GNUQQ
GUQSH
HCIFZ
HMCUK
HVGLF
HZ~
I-F
IAO
ICQ
IEA
IEP
IGS
IH2
IHR
INH
INR
IOF
IPY
ISR
ITC
K6-
KB.
KOO
L6V
L7B
LK5
LK8
LSO
M0K
M0L
M1P
M2M
M2O
M2P
M7P
M7R
M7S
N9A
NAPCQ
NEJ
NEPJS
O9-
OBC
OES
OHH
OMK
OVD
P-O
P2P
P62
PATMY
PCBAR
PDBOC
PM3
PQQKQ
PROAC
PSQYO
PSYQQ
PTHSS
PYCSY
Q2X
R05
RND
RNS
RNT
RNTTT
RXW
S0X
SC5
SHXYY
SIXXV
SJFOW
SJN
SNYQT
SV3
TAE
TAOOD
TBHMF
TDRGL
TEORI
TH9
TN5
TSG
TUS
TWZ
U5U
UIG
UKHRP
UKR
UMD
UQL
VQA
VVN
WH7
WOW
X7M
XIH
XKW
XZL
Y6R
YAE
YCJ
YFH
YNT
YOC
YQT
YR2
YXB
YZZ
ZCA
ZE2
ZKB
~02
~7V
~88
~8M
~KM
AAYZH
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
AADEA
AAEXX
ABEEJ
ADFPY
ADZGE
AETEA
NXXTH
AADWK
AAGJQ
AAJMP
AAYJO
ABGIJ
ACBMV
ACBRV
ACBYP
ACIGE
ACTTH
ACVWB
ADMDM
ADQMX
AEDAW
AEFTE
AFNRJ
AGGBP
AGPPL
AHGBK
AHPSJ
AJDOV
AMRJV
I-U
U1R
XFK
ZA5
AAPBV
ABGFU
ABPTK
AEQTP
7QG
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7TG
7TK
7TM
7TO
7U9
7XB
8FD
8FK
C1K
FR3
H94
K9.
KL.
M7N
MBDVC
P64
PQEST
PQUKI
Q9U
RC3
SOI
5PM
ID FETCH-LOGICAL-c690t-7c4656334be734b08aa94bc340d548157b18c5c211fa7af901426bad1f0837b3
IEDL.DBID 8C1
ISSN 0028-0836
IngestDate Tue Sep 17 21:21:13 EDT 2024
Thu Oct 10 21:17:38 EDT 2024
Thu Feb 22 23:36:54 EST 2024
Fri Feb 02 05:01:33 EST 2024
Tue Dec 12 21:15:54 EST 2023
Fri Feb 02 04:12:43 EST 2024
Thu Aug 01 20:19:18 EDT 2024
Thu Aug 01 20:19:29 EDT 2024
Thu Sep 26 17:50:31 EDT 2024
Tue Oct 15 23:46:45 EDT 2024
Fri Oct 11 20:46:13 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7511
Language English
License Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c690t-7c4656334be734b08aa94bc340d548157b18c5c211fa7af901426bad1f0837b3
Notes These authors contributed equally to this work.
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC4244910
PMID 25043025
PQID 1551986268
PQPubID 40569
PageCount 5
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4244910
proquest_journals_1551986268
gale_infotracmisc_A376934454
gale_infotracgeneralonefile_A376934454
gale_infotraccpiq_376934454
gale_infotracacademiconefile_A376934454
gale_incontextgauss_ISR_A376934454
gale_incontextgauss_ATWCN_A376934454
crossref_primary_10_1038_nature13393
pubmed_primary_25043025
springer_journals_10_1038_nature13393
PublicationCentury 2000
PublicationDate 7-31-2014
PublicationDateYYYYMMDD 2014-07-31
PublicationDate_xml – month: 07
  year: 2014
  text: 7-31-2014
  day: 31
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationSubtitle International weekly journal of science
PublicationTitle Nature (London)
PublicationTitleAbbrev Nature
PublicationTitleAlternate Nature
PublicationYear 2014
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Serizawa (CR19) 1995; 374
Rahl (CR22) 2010; 141
Sanda (CR21) 2012; 22
Bartkowiak (CR15) 2010; 24
O’Neil, Look (CR1) 2007; 26
Larochelle (CR9) 2012; 19
Shiekhattar (CR20) 1995; 374
Lovén (CR27) 2013; 153
Berg (CR2) 2008; 12
Fisher, Morgan (CR10) 1994; 78
Feaver, Svejstrup, Henry, Kornberg (CR18) 1994; 79
Chapuy (CR25) 2013; 24
Huang da, Sherman, Lempicki (CR17) 2009; 37
Lovén (CR30) 2012; 151
Sansó, Fisher (CR4) 2013; 4
Drapkin, Le Roy, Cho, Akoulitchev, Reinberg (CR7) 1996; 93
Garnett (CR16) 2012; 483
Larochelle (CR11) 2007; 25
Lu (CR3) 2012; 17
Glover-Cutter (CR8) 2009; 29
Hnisz (CR26) 2013; 155
Mäkelä (CR12) 1994; 371
Watanabe (CR23) 2000; 5
Solomon, Lee, Kirschner (CR14) 1992; 3
Yamada (CR24) 2006; 21
Nottingham (CR29) 2007; 110
Schachter (CR13) 2013; 50
Akhtar (CR6) 2009; 34
Patricelli (CR5) 2007; 46
Shi (CR28) 2013; 27
22392809 - J Biomol Screen. 2012 Jun;17(5):555-71
24119843 - Cell. 2013 Nov 7;155(4):934-47
20952539 - Genes Dev. 2010 Oct 15;24(20):2303-16
22897851 - Cancer Cell. 2012 Aug 14;22(2):209-21
25117707 - Cancer Cell. 2014 Aug 11;26(2):158-9
1532335 - Mol Biol Cell. 1992 Jan;3(1):13-27
19667075 - Mol Cell Biol. 2009 Oct;29(20):5455-64
18706517 - Curr Opin Chem Biol. 2008 Aug;12(4):464-71
19033363 - Nucleic Acids Res. 2009 Jan;37(1):1-13
23582323 - Cell. 2013 Apr 11;153(2):320-34
8069918 - Cell. 1994 Aug 26;78(4):713-24
22460902 - Nature. 2012 Mar 29;483(7391):570-5
8001136 - Cell. 1994 Dec 16;79(6):1103-9
23064645 - Nat Struct Mol Biol. 2012 Nov;19(11):1108-15
17823307 - Blood. 2007 Dec 15;110(13):4188-97
20434984 - Cell. 2010 Apr 30;141(3):432-45
23756342 - Transcription. 2013 Jul-Aug;4(4):146-52
8692842 - Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6488-93
24285714 - Genes Dev. 2013 Dec 15;27(24):2648-62
10886368 - Genes Cells. 2000 May;5(5):407-23
23622515 - Mol Cell. 2013 Apr 25;50(2):250-60
7885450 - Nature. 1995 Mar 16;374(6519):280-2
17934490 - Oncogene. 2007 Oct 15;26(47):6838-49
19450536 - Mol Cell. 2009 May 15;34(3):387-93
23101621 - Cell. 2012 Oct 26;151(3):476-82
16427012 - Mol Cell. 2006 Jan 20;21(2):227-37
7533895 - Nature. 1995 Mar 16;374(6519):283-7
8078587 - Nature. 1994 Sep 15;371(6494):254-7
17386261 - Mol Cell. 2007 Mar 23;25(6):839-50
24332044 - Cancer Cell. 2013 Dec 9;24(6):777-90
17209545 - Biochemistry. 2007 Jan 16;46(2):350-8
M Sansó (BFnature13393_CR4) 2013; 4
PB Rahl (BFnature13393_CR22) 2010; 141
TP Mäkelä (BFnature13393_CR12) 1994; 371
J Shi (BFnature13393_CR28) 2013; 27
WT Nottingham (BFnature13393_CR29) 2007; 110
RP Fisher (BFnature13393_CR10) 1994; 78
K Glover-Cutter (BFnature13393_CR8) 2009; 29
J Lovén (BFnature13393_CR27) 2013; 153
J Lovén (BFnature13393_CR30) 2012; 151
R Shiekhattar (BFnature13393_CR20) 1995; 374
MM Schachter (BFnature13393_CR13) 2013; 50
MP Patricelli (BFnature13393_CR5) 2007; 46
MS Akhtar (BFnature13393_CR6) 2009; 34
T Yamada (BFnature13393_CR24) 2006; 21
Q Lu (BFnature13393_CR3) 2012; 17
Y Watanabe (BFnature13393_CR23) 2000; 5
B Chapuy (BFnature13393_CR25) 2013; 24
B Bartkowiak (BFnature13393_CR15) 2010; 24
H Serizawa (BFnature13393_CR19) 1995; 374
R Drapkin (BFnature13393_CR7) 1996; 93
S Larochelle (BFnature13393_CR11) 2007; 25
WJ Feaver (BFnature13393_CR18) 1994; 79
MJ Garnett (BFnature13393_CR16) 2012; 483
T Sanda (BFnature13393_CR21) 2012; 22
T Berg (BFnature13393_CR2) 2008; 12
J O’Neil (BFnature13393_CR1) 2007; 26
D Hnisz (BFnature13393_CR26) 2013; 155
S Larochelle (BFnature13393_CR9) 2012; 19
MJ Solomon (BFnature13393_CR14) 1992; 3
W Huang da (BFnature13393_CR17) 2009; 37
References_xml – volume: 46
  start-page: 350
  year: 2007
  end-page: 358
  ident: CR5
  article-title: Functional interrogation of the kinome using nucleotide acyl phosphates
  publication-title: Biochemistry
  doi: 10.1021/bi062142x
  contributor:
    fullname: Patricelli
– volume: 4
  start-page: 146
  year: 2013
  end-page: 152
  ident: CR4
  article-title: Pause, play, repeat: CDKs push RNAP II’s buttons
  publication-title: Transcription
  doi: 10.4161/trns.25146
  contributor:
    fullname: Fisher
– volume: 141
  start-page: 432
  year: 2010
  end-page: 445
  ident: CR22
  article-title: c-Myc regulates transcriptional pause release
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.030
  contributor:
    fullname: Rahl
– volume: 153
  start-page: 320
  year: 2013
  end-page: 334
  ident: CR27
  article-title: Selective inhibition of tumor oncogenes by disruption of super-enhancers
  publication-title: Cell
  doi: 10.1016/j.cell.2013.03.036
  contributor:
    fullname: Lovén
– volume: 19
  start-page: 1108
  year: 2012
  end-page: 1115
  ident: CR9
  article-title: Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
  publication-title: Nature Struct. Mol. Biol.
  doi: 10.1038/nsmb.2399
  contributor:
    fullname: Larochelle
– volume: 3
  start-page: 13
  year: 1992
  end-page: 27
  ident: CR14
  article-title: Role of phosphorylation in p34cdc2 activation: identification of an activating kinase
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.3.1.13
  contributor:
    fullname: Kirschner
– volume: 24
  start-page: 777
  year: 2013
  end-page: 790
  ident: CR25
  article-title: Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2013.11.003
  contributor:
    fullname: Chapuy
– volume: 27
  start-page: 2648
  year: 2013
  end-page: 2662
  ident: CR28
  article-title: Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
  publication-title: Genes Dev.
  doi: 10.1101/gad.232710.113
  contributor:
    fullname: Shi
– volume: 78
  start-page: 713
  year: 1994
  end-page: 724
  ident: CR10
  article-title: A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
  publication-title: Cell
  doi: 10.1016/0092-8674(94)90535-5
  contributor:
    fullname: Morgan
– volume: 155
  start-page: 934
  year: 2013
  end-page: 947
  ident: CR26
  article-title: Super-enhancers in the control of cell identity and disease
  publication-title: Cell
  doi: 10.1016/j.cell.2013.09.053
  contributor:
    fullname: Hnisz
– volume: 371
  start-page: 254
  year: 1994
  end-page: 257
  ident: CR12
  article-title: A cyclin associated with the CDK-activating kinase MO15
  publication-title: Nature
  doi: 10.1038/371254a0
  contributor:
    fullname: Mäkelä
– volume: 374
  start-page: 283
  year: 1995
  end-page: 287
  ident: CR20
  article-title: Cdk-activating kinase complex is a component of human transcription factor TFIIH
  publication-title: Nature
  doi: 10.1038/374283a0
  contributor:
    fullname: Shiekhattar
– volume: 21
  start-page: 227
  year: 2006
  end-page: 237
  ident: CR24
  article-title: P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2005.11.024
  contributor:
    fullname: Yamada
– volume: 374
  start-page: 280
  year: 1995
  end-page: 282
  ident: CR19
  article-title: Association of Cdk-activating kinase subunits with transcription factor TFIIH
  publication-title: Nature
  doi: 10.1038/374280a0
  contributor:
    fullname: Serizawa
– volume: 29
  start-page: 5455
  year: 2009
  end-page: 5464
  ident: CR8
  article-title: TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00637-09
  contributor:
    fullname: Glover-Cutter
– volume: 34
  start-page: 387
  year: 2009
  end-page: 393
  ident: CR6
  article-title: TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2009.04.016
  contributor:
    fullname: Akhtar
– volume: 25
  start-page: 839
  year: 2007
  end-page: 850
  ident: CR11
  article-title: Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2007.02.003
  contributor:
    fullname: Larochelle
– volume: 17
  start-page: 555
  year: 2012
  end-page: 571
  ident: CR3
  article-title: Perspectives on the discovery of small-molecule modulators for epigenetic processes
  publication-title: J. Biomol. Screen.
  doi: 10.1177/1087057112437763
  contributor:
    fullname: Lu
– volume: 22
  start-page: 209
  year: 2012
  end-page: 221
  ident: CR21
  article-title: Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.06.007
  contributor:
    fullname: Sanda
– volume: 110
  start-page: 4188
  year: 2007
  end-page: 4197
  ident: CR29
  article-title: Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer
  publication-title: Blood
  doi: 10.1182/blood-2007-07-100883
  contributor:
    fullname: Nottingham
– volume: 5
  start-page: 407
  year: 2000
  end-page: 423
  ident: CR23
  article-title: Modulation of TFIIH-associated kinase activity by complex formation and its relationship with CTD phosphorylation of RNA polymerase II
  publication-title: Genes Cells
  doi: 10.1046/j.1365-2443.2000.00336.x
  contributor:
    fullname: Watanabe
– volume: 24
  start-page: 2303
  year: 2010
  end-page: 2316
  ident: CR15
  article-title: CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1
  publication-title: Genes Dev.
  doi: 10.1101/gad.1968210
  contributor:
    fullname: Bartkowiak
– volume: 79
  start-page: 1103
  year: 1994
  end-page: 1109
  ident: CR18
  article-title: Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
  publication-title: Cell
  doi: 10.1016/0092-8674(94)90040-X
  contributor:
    fullname: Kornberg
– volume: 26
  start-page: 6838
  year: 2007
  end-page: 6849
  ident: CR1
  article-title: Mechanisms of transcription factor deregulation in lymphoid cell transformation
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210766
  contributor:
    fullname: Look
– volume: 37
  start-page: 1
  year: 2009
  end-page: 13
  ident: CR17
  article-title: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkn923
  contributor:
    fullname: Lempicki
– volume: 151
  start-page: 476
  year: 2012
  end-page: 482
  ident: CR30
  article-title: Revisiting global gene expression analysis
  publication-title: Cell
  doi: 10.1016/j.cell.2012.10.012
  contributor:
    fullname: Lovén
– volume: 93
  start-page: 6488
  year: 1996
  end-page: 6493
  ident: CR7
  article-title: Human cyclin-dependent kinase-activating kinase exists in three distinct complexes
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.93.13.6488
  contributor:
    fullname: Reinberg
– volume: 12
  start-page: 464
  year: 2008
  end-page: 471
  ident: CR2
  article-title: Inhibition of transcription factors with small organic molecules
  publication-title: Curr. Opin. Chem. Biol.
  doi: 10.1016/j.cbpa.2008.07.023
  contributor:
    fullname: Berg
– volume: 483
  start-page: 570
  year: 2012
  end-page: 575
  ident: CR16
  article-title: Systematic identification of genomic markers of drug sensitivity in cancer cells
  publication-title: Nature
  doi: 10.1038/nature11005
  contributor:
    fullname: Garnett
– volume: 50
  start-page: 250
  year: 2013
  end-page: 260
  ident: CR13
  article-title: A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2013.04.003
  contributor:
    fullname: Schachter
– volume: 19
  start-page: 1108
  year: 2012
  ident: BFnature13393_CR9
  publication-title: Nature Struct. Mol. Biol.
  doi: 10.1038/nsmb.2399
  contributor:
    fullname: S Larochelle
– volume: 12
  start-page: 464
  year: 2008
  ident: BFnature13393_CR2
  publication-title: Curr. Opin. Chem. Biol.
  doi: 10.1016/j.cbpa.2008.07.023
  contributor:
    fullname: T Berg
– volume: 78
  start-page: 713
  year: 1994
  ident: BFnature13393_CR10
  publication-title: Cell
  doi: 10.1016/0092-8674(94)90535-5
  contributor:
    fullname: RP Fisher
– volume: 3
  start-page: 13
  year: 1992
  ident: BFnature13393_CR14
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.3.1.13
  contributor:
    fullname: MJ Solomon
– volume: 79
  start-page: 1103
  year: 1994
  ident: BFnature13393_CR18
  publication-title: Cell
  doi: 10.1016/0092-8674(94)90040-X
  contributor:
    fullname: WJ Feaver
– volume: 25
  start-page: 839
  year: 2007
  ident: BFnature13393_CR11
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2007.02.003
  contributor:
    fullname: S Larochelle
– volume: 29
  start-page: 5455
  year: 2009
  ident: BFnature13393_CR8
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00637-09
  contributor:
    fullname: K Glover-Cutter
– volume: 5
  start-page: 407
  year: 2000
  ident: BFnature13393_CR23
  publication-title: Genes Cells
  doi: 10.1046/j.1365-2443.2000.00336.x
  contributor:
    fullname: Y Watanabe
– volume: 27
  start-page: 2648
  year: 2013
  ident: BFnature13393_CR28
  publication-title: Genes Dev.
  doi: 10.1101/gad.232710.113
  contributor:
    fullname: J Shi
– volume: 155
  start-page: 934
  year: 2013
  ident: BFnature13393_CR26
  publication-title: Cell
  doi: 10.1016/j.cell.2013.09.053
  contributor:
    fullname: D Hnisz
– volume: 24
  start-page: 2303
  year: 2010
  ident: BFnature13393_CR15
  publication-title: Genes Dev.
  doi: 10.1101/gad.1968210
  contributor:
    fullname: B Bartkowiak
– volume: 21
  start-page: 227
  year: 2006
  ident: BFnature13393_CR24
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2005.11.024
  contributor:
    fullname: T Yamada
– volume: 50
  start-page: 250
  year: 2013
  ident: BFnature13393_CR13
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2013.04.003
  contributor:
    fullname: MM Schachter
– volume: 26
  start-page: 6838
  year: 2007
  ident: BFnature13393_CR1
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210766
  contributor:
    fullname: J O’Neil
– volume: 374
  start-page: 283
  year: 1995
  ident: BFnature13393_CR20
  publication-title: Nature
  doi: 10.1038/374283a0
  contributor:
    fullname: R Shiekhattar
– volume: 371
  start-page: 254
  year: 1994
  ident: BFnature13393_CR12
  publication-title: Nature
  doi: 10.1038/371254a0
  contributor:
    fullname: TP Mäkelä
– volume: 141
  start-page: 432
  year: 2010
  ident: BFnature13393_CR22
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.030
  contributor:
    fullname: PB Rahl
– volume: 151
  start-page: 476
  year: 2012
  ident: BFnature13393_CR30
  publication-title: Cell
  doi: 10.1016/j.cell.2012.10.012
  contributor:
    fullname: J Lovén
– volume: 34
  start-page: 387
  year: 2009
  ident: BFnature13393_CR6
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2009.04.016
  contributor:
    fullname: MS Akhtar
– volume: 153
  start-page: 320
  year: 2013
  ident: BFnature13393_CR27
  publication-title: Cell
  doi: 10.1016/j.cell.2013.03.036
  contributor:
    fullname: J Lovén
– volume: 22
  start-page: 209
  year: 2012
  ident: BFnature13393_CR21
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.06.007
  contributor:
    fullname: T Sanda
– volume: 374
  start-page: 280
  year: 1995
  ident: BFnature13393_CR19
  publication-title: Nature
  doi: 10.1038/374280a0
  contributor:
    fullname: H Serizawa
– volume: 110
  start-page: 4188
  year: 2007
  ident: BFnature13393_CR29
  publication-title: Blood
  doi: 10.1182/blood-2007-07-100883
  contributor:
    fullname: WT Nottingham
– volume: 37
  start-page: 1
  year: 2009
  ident: BFnature13393_CR17
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkn923
  contributor:
    fullname: W Huang da
– volume: 46
  start-page: 350
  year: 2007
  ident: BFnature13393_CR5
  publication-title: Biochemistry
  doi: 10.1021/bi062142x
  contributor:
    fullname: MP Patricelli
– volume: 4
  start-page: 146
  year: 2013
  ident: BFnature13393_CR4
  publication-title: Transcription
  doi: 10.4161/trns.25146
  contributor:
    fullname: M Sansó
– volume: 24
  start-page: 777
  year: 2013
  ident: BFnature13393_CR25
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2013.11.003
  contributor:
    fullname: B Chapuy
– volume: 93
  start-page: 6488
  year: 1996
  ident: BFnature13393_CR7
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.93.13.6488
  contributor:
    fullname: R Drapkin
– volume: 17
  start-page: 555
  year: 2012
  ident: BFnature13393_CR3
  publication-title: J. Biomol. Screen.
  doi: 10.1177/1087057112437763
  contributor:
    fullname: Q Lu
– volume: 483
  start-page: 570
  year: 2012
  ident: BFnature13393_CR16
  publication-title: Nature
  doi: 10.1038/nature11005
  contributor:
    fullname: MJ Garnett
SSID ssj0005174
Score 2.6705356
Snippet Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia...
Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacological...
Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state (1), but direct pharmacological...
Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state 1 , but direct pharmacological...
SourceID pubmedcentral
proquest
gale
crossref
pubmed
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 616
SubjectTerms 38/61
45/15
59/5
631/154/555
631/67/1990/283
631/67/395
631/92/275
82/58
96/2
96/31
96/98
Analysis
Antineoplastic Agents - pharmacology
Cancer
Care and treatment
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Core Binding Factor Alpha 2 Subunit - metabolism
Crystal structure
Cyclin-Dependent Kinases - antagonists & inhibitors
Cysteine
Cysteine - metabolism
Enzyme Inhibitors - pharmacology
Experiments
Gene expression
Gene Expression Regulation, Neoplastic - drug effects
Genetic aspects
Genetic regulation
Genetic transcription
Health aspects
Humanities and Social Sciences
Humans
Jurkat Cells
Kinases
letter
Leukemia
multidisciplinary
Pharmacology
Phenylenediamines - pharmacology
Phosphorylation
Phosphorylation - drug effects
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - enzymology
Pyrimidines - pharmacology
Regression analysis
Science
Transcription factors
Title Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
URI https://link.springer.com/article/10.1038/nature13393
https://www.ncbi.nlm.nih.gov/pubmed/25043025
https://www.proquest.com/docview/1551986268
https://pubmed.ncbi.nlm.nih.gov/PMC4244910
Volume 511
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED-xTUi8IDY-FjYqC42vh2hN7cbOEyplZTBRoVFE3yzHcba-pF3T_f_cJc5IysRLVOkuqXU-34d9_h3ACWYZMWYNLsToXIXCyTw0bqBCkycqjYTN4qo34PdpfP5LfJsP537DrfRllY1NrAx1trS0R35Krj2h8Ft9XN2E1DWKTld9C40d2ItQMal1gxq3Sjy2UJj9_bw-V6c1bCYmaAnveKRtu9xyTNtFk1snp5VDmjyBxz6SZKN66vfhgSsO4GFV0WnLA9j3q7Zk7z209IencDGrCr_xe2xDTqoxGWxdt6Snn4uCWVKFNaM9WmaYXaI24nDY-POFRPL1IkUzsH4Gs8nZbHwe-nYKocUUeBNKS9honIvUSXz0lTGJSC0X_WxIkC0yjZQdWswIcyNxrjB5GsSpyaIcZSdT_hx2i2XhDoG5fp5YDMsJK05kkcHX4thgcuKsHHA7COCkkahe1aAZujrs5kq3BI9sJG1NMBQF1blcmduy1KPZ7_FUjzh1aRRiKAJ4fR_b15-XHaZ3nilfogCt8bcLcMAEcNXhPOpw2tXiRreobzvUq3qG7vvMcYcRV6XtkhsV0t4qlPqvDgfwotamO_lUUHIYgAYgO3p2x0A44F1Ksbiu8MDpriJGfQG8aTSy9Zf_iv3l_4d2BI8wKBT1_vUx7G7Wt-4VBl6btAc7ci571Rqj5-RLD_Y-nU1_XP4BTWEtyg
link.rule.ids 230,315,786,790,891,12083,12250,12792,21416,27955,27956,31752,33299,33406,33777,43343,43612,43633,43838,74100,74369,74390,74657
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9BJwQviI2vsAEWGl8P0drajZ0nVMqmjm4VGkHbm-U4ztaXtGu6_5-7xNmaMvESVbprYp3P92Gffwewj1lGhFmDCzE6V6FwMg-N66vQ5LFKe8JmUdUb8HQajf-InxeDC7_hVvqyysYmVoY6m1vaIz8g1x5T-K2-La5D6hpFp6u-hcZD2CLITdWBre-H019nd0UeGzjM_oZel6uDGjgTU7SYt3zSpmVec02bZZMbZ6eVSzp6Bk99LMmG9eRvwwNX7MCjqqbTljuw7ddtyb54cOmvz2GSVKXf-D62IjfVGA22rJvS089ZwSwpw5LRLi0zzM5RH3E4bPRjIpF8NUvRECxfQHJ0mIzGoW-oEFpMglehtISOxrlIncRHVxkTi9Ry0c0GBNoi056yA4s5YW4kzhamT_0oNVkvR9nJlL-ETjEv3GtgrpvHFgNzQosTWc_g36LIYHrirOxz2w9gv5GoXtSwGbo67uZKrwke2UjamoAoCqp0uTQ3ZamHyfloqoec-jQKMRABfLiP7fj3WYvps2fK5yhAa_z9AhwwQVy1OHdbnHYxu9Zr1E8t6mU9Q_e9Zq_FiOvStsmNCmlvF0p9p8UBvKq16VY-FZgchqAByJae3TIQEnibUsyuKkRwuq2IcV8AHxuNXPvkv2J_8_-hvYfH4-T0RJ8cTye78ARDRFHvZu9BZ7W8cW8xDFul7_xa-wuaXy73
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED-NTSBeEBtfYQMsNL4eoqa1GydPqOpWbRQqBEX0zXKcZOtL2jXd_8-d42x1mfYSVbprYp3P92GffwdwjFlGjFlDEWJ0noSikGWoi14S6jJNsq4weWx7A_6YxGd_xLdZf-bqn2pXVtnaRGuo84WhPfIOufaUwu-kU7qyiJ8no6_Lq5A6SNFJq2un8QD20EtG1MZBzuRtuccWIrO7qxfxpNNAaGKylnLPO23b6A0ntV1AuXWKap3T6Ck8cVElGzRqsA87RXUAD211p6kPYN-t4Jp9djDTX57BeGqLwPF9bE0OqzUfbNW0p6ef84oZUosVo_1applZoGbicNjwZCyRfDnP0CSsnsN0dDodnoWutUJoMB1eh9IQThrnIiskPqJE61Rkhoso7xN8i8y6iekbzA5LLXHeMJHqxZnOuyXKTmb8BexWi6p4BayIytRgiE64cSLvavxbHGtMVAoje9z0AjhuJaqWDYCGsgffPFEbgkc2krYiSIqKJvdCX9e1Gkz_DidqwKljoxB9EcD7u9jOf__ymD45pnKBAjTa3TTAARPYlcd56HGa5fxKbVA_etSLZobues2Rx4gr1PjkVoWUsxC1utXnAF422nQjHwsrh8FoANLTsxsGwgT3KdX80mKD071FjAAD-NBq5MYn_xf76_uH9g4e4SJT388n40N4jLGiaLa1j2B3vbou3mA8ts7e2oX2D6zlMbQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Targeting+transcription+regulation+in+cancer+with+a+covalent+CDK7+inhibitor&rft.jtitle=Nature+%28London%29&rft.au=Kwiatkowski%2C+Nicholas&rft.au=Zhang%2C+Tinghu&rft.au=Rahl%2C+Peter+B&rft.au=Abraham%2C+Brian+J&rft.date=2014-07-31&rft.pub=Nature+Publishing+Group&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=511&rft.issue=7511&rft.spage=616&rft_id=info:doi/10.1038%2Fnature13393&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=3396333311
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon