The right central amygdala shows greater activation in response to an auditory conditioned stimulus in male rats
Pavlovian fear conditioning is an experimental procedure in which a conditioned stimulus (CS) acquires an ability to elicit fear responses. This type of conditioning depends on the basolateral complex of the amygdala (BLA) and/or central amygdala (CeA). We previously found that rats showed reduced f...
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| Published in | Journal of Veterinary Medical Science Vol. 78; no. 10; pp. 1563 - 1568 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
JAPANESE SOCIETY OF VETERINARY SCIENCE
2016
Japan Science and Technology Agency The Japanese Society of Veterinary Science |
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| Online Access | Get full text |
| ISSN | 0916-7250 1347-7439 1347-7439 |
| DOI | 10.1292/jvms.16-0255 |
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| Abstract | Pavlovian fear conditioning is an experimental procedure in which a conditioned stimulus (CS) acquires an ability to elicit fear responses. This type of conditioning depends on the basolateral complex of the amygdala (BLA) and/or central amygdala (CeA). We previously found that rats showed reduced fear responses to an auditory CS when they were subjected to a pre-training chemical lesion of the entire right amygdala as compared with the left amygdala. Based on this finding, we hypothesize that the BLA and/or CeA in the right hemisphere will be more strongly activated by an auditory CS than those in the left hemisphere. To test this hypothesis, we re-exposed fear-conditioned and non-conditioned rats to an auditory CS 1 day after fear conditioning. We assessed Fos expression in the BLA and CeA in each hemisphere. We found that fear-conditioned subjects showed fear responses, such as increased freezing and decreased walking, as well as increased Fos expression in the BLA and CeA. When we compared Fos expression between hemispheres, Fos expression in the CeA, but not the BLA, was greater in the right hemisphere compared with the left hemisphere. These results suggest that the right CeA is more strongly activated by the auditory CS. |
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| AbstractList | Pavlovian fear conditioning is an experimental procedure in which a conditioned stimulus (CS) acquires an ability to elicit fear responses. This type of conditioning depends on the basolateral complex of the amygdala (BLA) and/or central amygdala (CeA). We previously found that rats showed reduced fear responses to an auditory CS when they were subjected to a pre-training chemical lesion of the entire right amygdala as compared with the left amygdala. Based on this finding, we hypothesize that the BLA and/or CeA in the right hemisphere will be more strongly activated by an auditory CS than those in the left hemisphere. To test this hypothesis, we re-exposed fear-conditioned and non-conditioned rats to an auditory CS 1 day after fear conditioning. We assessed Fos expression in the BLA and CeA in each hemisphere. We found that fear-conditioned subjects showed fear responses, such as increased freezing and decreased walking, as well as increased Fos expression in the BLA and CeA. When we compared Fos expression between hemispheres, Fos expression in the CeA, but not the BLA, was greater in the right hemisphere compared with the left hemisphere. These results suggest that the right CeA is more strongly activated by the auditory CS.Pavlovian fear conditioning is an experimental procedure in which a conditioned stimulus (CS) acquires an ability to elicit fear responses. This type of conditioning depends on the basolateral complex of the amygdala (BLA) and/or central amygdala (CeA). We previously found that rats showed reduced fear responses to an auditory CS when they were subjected to a pre-training chemical lesion of the entire right amygdala as compared with the left amygdala. Based on this finding, we hypothesize that the BLA and/or CeA in the right hemisphere will be more strongly activated by an auditory CS than those in the left hemisphere. To test this hypothesis, we re-exposed fear-conditioned and non-conditioned rats to an auditory CS 1 day after fear conditioning. We assessed Fos expression in the BLA and CeA in each hemisphere. We found that fear-conditioned subjects showed fear responses, such as increased freezing and decreased walking, as well as increased Fos expression in the BLA and CeA. When we compared Fos expression between hemispheres, Fos expression in the CeA, but not the BLA, was greater in the right hemisphere compared with the left hemisphere. These results suggest that the right CeA is more strongly activated by the auditory CS. Pavlovian fear conditioning is an experimental procedure in which a conditioned stimulus (CS) acquires an ability to elicit fear responses. This type of conditioning depends on the basolateral complex of the amygdala (BLA) and/or central amygdala (CeA). We previously found that rats showed reduced fear responses to an auditory CS when they were subjected to a pre-training chemical lesion of the entire right amygdala as compared with the left amygdala. Based on this finding, we hypothesize that the BLA and/or CeA in the right hemisphere will be more strongly activated by an auditory CS than those in the left hemisphere. To test this hypothesis, we re-exposed fear-conditioned and non-conditioned rats to an auditory CS 1 day after fear conditioning. We assessed Fos expression in the BLA and CeA in each hemisphere. We found that fear-conditioned subjects showed fear responses, such as increased freezing and decreased walking, as well as increased Fos expression in the BLA and CeA. When we compared Fos expression between hemispheres, Fos expression in the CeA, but not the BLA, was greater in the right hemisphere compared with the left hemisphere. These results suggest that the right CeA is more strongly activated by the auditory CS. Pavlovian fear conditioning is an experimental procedure in which a conditioned stimulus (CS) acquires an ability to elicit fear responses. This type of conditioning depends on the basolateral complex of the amygdala (BLA) and/or central amygdala (CeA). We previously found that rats showed reduced fear responses to an auditory CS when they were subjected to a pre-training chemical lesion of the entire right amygdala as compared with the left amygdala. Based on this finding, we hypothesize that the BLA and/or CeA in the right hemisphere will be more strongly activated by an auditory CS than those in the left hemisphere. To test this hypothesis, we re-exposed fear-conditioned and non-conditioned rats to an auditory CS 1 day after fear conditioning. We assessed Fos expression in the BLA and CeA in each hemisphere. We found that fear-conditioned subjects showed fear responses, such as increased freezing and decreased walking, as well as increased Fos expression in the BLA and CeA. When we compared Fos expression between hemispheres, Fos expression in the CeA, but not the BLA, was greater in the right hemisphere compared with the left hemisphere. These results suggest that the right CeA is more strongly activated by the auditory CS. |
| Author | KIYOKAWA, Yasushi TAKAHASHI, Daichi MORI, Yuji TAKEUCHI, Yukari |
| Author_xml | – sequence: 1 fullname: TAKEUCHI, Yukari organization: Laboratory of Veterinary Ethology, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan – sequence: 1 fullname: MORI, Yuji organization: Laboratory of Veterinary Ethology, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan – sequence: 1 fullname: KIYOKAWA, Yasushi organization: Laboratory of Veterinary Ethology, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan – sequence: 1 fullname: TAKAHASHI, Daichi organization: Laboratory of Veterinary Ethology, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27320818$$D View this record in MEDLINE/PubMed |
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| References_xml | – reference: 2. Baker, K. B. and Kim, J. J. 2004. Amygdalar lateralization in fear conditioning: evidence for greater involvement of the right amygdala. Behav. Neurosci. 118: 15–23. – reference: 29. Waters, N. S. and Denenberg, V. H. 1994. Analysis of two measures of paw preference in a large population of inbred mice. Behav. Brain Res. 63: 195–204. – reference: 20. LaBar, K. S. and LeDoux, J. E. 1996. Partial disruption of fear conditioning in rats with unilateral amygdala damage: correspondence with unilateral temporal lobectomy in humans. Behav. Neurosci. 110: 991–997. – reference: 5. Carrasquillo, Y. and Gereau, R. W. 4th 2007. Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception. J. Neurosci. 27: 1543–1551. – reference: 30. Wells, D. L. 2003. Lateralised behaviour in the domestic dog, Canis familiaris. Behav. Processes 61: 27–35. – reference: 24. Muyama, H., Kiyokawa, Y., Inagaki, H., Takeuchi, Y. and Mori, Y. 2016. Alarm pheromone does not modulate 22-kHz calls in male rats. Physiol. Behav. 156: 59–63. – reference: 15. Kiyokawa, Y., Kodama, Y., Takeuchi, Y. and Mori, Y. 2013. Physical interaction is not necessary for the induction of housing-type social buffering of conditioned hyperthermia in male rats. Behav. Brain Res. 256: 414–419. – reference: 9. Glick, S. D. and Jerussi, T. P. 1974. Spatial and paw preferences in rats: their relationship to rate-dependent effects of d-amphetamine. J. Pharmacol. Exp. Ther. 188: 714–725. – reference: 11. Ishii, A., Kiyokawa, Y., Takeuchi, Y. and Mori, Y. 2016. Social buffering ameliorates conditioned fear responses in female rats. Horm. Behav. 81: 53–58. – reference: 13. Kiyokawa, Y. 2015. Social Odors: Alarm Pheromones and Social Buffering. Curr. Top. Behav. Neurosci. – reference: 26. Schafe, G. E., Atkins, C. M., Swank, M. W., Bauer, E. P., Sweatt, J. D. and LeDoux, J. E. 2000. 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| SubjectTerms | Acoustic Stimulation - veterinary Amygdala Animals auditory fear conditioning Central Amygdaloid Nucleus - physiology Conditioning, Classical Dominance, Cerebral Ethology Fear Fear conditioning fear responses Fos expression Hemispheric laterality lateralization Male Rats Rats, Wistar Rodents Tonic immobility Walking |
| Title | The right central amygdala shows greater activation in response to an auditory conditioned stimulus in male rats |
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