Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

• Published in: Journal of the American Academy of Child and Adolescent Psychiatry Vol. 61; no. 7; pp. 934 - 945
• Main Authors: Jami, Eshim S., Hammerschlag, Anke R., Ip, Hill F., Allegrini, Andrea G., Benyamin, Beben, Border, Richard, Diemer, Elizabeth W., Jiang, Chang, Karhunen, Ville, Lu, Yi, Lu, Qing, Mallard, Travis T., Mishra, Pashupati P., Nolte, Ilja M., Palviainen, Teemu, Peterson, Roseann E., Sallis, Hannah M., Shabalin, Andrey A., Tate, Ashley E., Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Wang, Carol, Zhou, Ang, Adkins, Daniel E., Alemany, Silvia, Ask, Helga, Chen, Qi, Corley, Robin P., Ehli, Erik A., Evans, Luke M., Havdahl, Alexandra, Hagenbeek, Fiona A., Hakulinen, Christian, Henders, Anjali K., Hottenga, Jouke Jan, Korhonen, Tellervo, Mamun, Abdullah, Marrington, Shelby, Neumann, Alexander, Rimfeld, Kaili, Rivadeneira, Fernando, Silberg, Judy L., van Beijsterveldt, Catharina E., Vuoksimaa, Eero, Whipp, Alyce M., Tong, Xiaoran, Andreassen, Ole A., Boomsma, Dorret I., Brown, Sandra A., Burt, S. Alexandra, Copeland, William, Dick, Danielle M., Harden, K. Paige, Harris, Kathleen Mullan, Hartman, Catharina A., Heinrich, Joachim, Hewitt, John K., Hopfer, Christian, Hypponen, Elina, Jarvelin, Marjo-Riitta, Kaprio, Jaakko, Keltikangas-Järvinen, Liisa, Klump, Kelly L., Krauter, Kenneth, Kuja-Halkola, Ralf, Larsson, Henrik, Lehtimäki, Terho, Lichtenstein, Paul, Lundström, Sebastian, Maes, Hermine H., Magnus, Per, Munafò, Marcus R., Najman, Jake M., Njølstad, Pål R., Oldehinkel, Albertine J., Pennell, Craig E., Plomin, Robert, Reichborn-Kjennerud, Ted, Reynolds, Chandra, Rose, Richard J., Smolen, Andrew, Snieder, Harold, Stallings, Michael, Standl, Marie, Sunyer, Jordi, Tiemeier, Henning, Wadsworth, Sally J., Wall, Tamara L., Whitehouse, Andrew J.O., Williams, Gail M., Ystrøm, Eivind, Nivard, Michel G., Bartels, Meike, Middeldorp, Christel M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2022; Elsevier BV
• Subjects: Adolescent; Adolescents; Adult; Adults; Age; Aggression; Anorexia; Anxiety; Anxiety - genetics; Associations; Attention Deficit Disorder with Hyperactivity - genetics; Attention deficit hyperactivity disorder; Autism; Autistic Disorder - genetics; behavioral-problems; Bipolar Disorder; Child; Child development; Child, Preschool; Childhood; Children; Comorbidity; Consortia; depression; Depression - genetics; Eating disorders; Estimates; Fathers; Genes; Genetic analysis; genetic epidemiology; genetics; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomics; Heritability; Humans; Hyperactivity; Insomnia; Internalization; Internalizing disorders; Loneliness; Longitudinal studies; major depressive disorder; Mental depression; Mental disorders; Meta-analysis; molecular; molecular genetics; Obsessive compulsive disorder; Pediatrics; Polymorphism, Single Nucleotide; prevalence; Psychiatric/Mental Health; Psychiatry; Psychology; psychopathology; Psykiatri; Quality control; questionnaire; repeated measures; risk; Sample size; Schizophrenia; Single-nucleotide polymorphism; Sleep disorders; Sleep Initiation and Maintenance Disorders - genetics; Statistics; Subsets; Teachers; Well being; Within-subjects design; Young Children; molecular genetics; anxiety; depression; repeated measures; genetic epidemiology

To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and...