Dynamic changes in human-gut microbiome in relation to a placebo-controlled anthelminthic trial in Indonesia

• Published in: PLoS neglected tropical diseases Vol. 12; no. 8; p. e0006620
• Main Authors: Martin, Ivonne, Djuardi, Yenny, Sartono, Erliyani, Rosa, Bruce A., Supali, Taniawati, Mitreva, Makedonka, Houwing-Duistermaat, Jeanine J., Yazdanbakhsh, Maria
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2018; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Albendazole; Albendazole - administration & dosage; Albendazole - pharmacology; Anthelmintics - administration & dosage; Anthelmintics - pharmacology; Bacteria; Bacteria - drug effects; Bacteria - genetics; Bacteroidetes; Biology and Life Sciences; Care and treatment; Child; Complexity; Composition; Development and progression; Digestive system; Dirichlet problem; Double-Blind Method; Family Characteristics; Female; Gastrointestinal Microbiome - drug effects; Gastrointestinal system; Generalized linear models; Genomes; Health aspects; Helminthiasis; Host-bacteria relationships; Humans; Immune system; Indonesia; Infections; Intestinal flora; Intestinal microflora; Male; Medical examination; Medicine; Medicine and Health Sciences; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Parasitology; Profiles; Regression analysis; Regression models; Relative abundance; Research and Analysis Methods; RNA, Bacterial; RNA, Ribosomal, 16S; Soil; Statistical analysis; Statistical methods; Studies; Tropical diseases; Young Adult; Indonesia; Jakarta Indonesia; Netherlands; United States > US; Missouri; Zimbabwe; Malaysia

Microbiome studies suggest the presence of an interaction between the human gut microbiome and soil-transmitted helminth. Upon deworming, a complex interaction between the anthelminthic drug, helminths and microbiome composition might occur. To dissect this, we analyse the changes that take place in...