Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation to analyze extracellular viral markers

• Published in: PLoS computational biology Vol. 20; no. 3; p. e1011238
• Main Authors: Kitagawa, Kosaku, Kim, Kwang Su, Iwamoto, Masashi, Hayashi, Sanae, Park, Hyeongki, Nishiyama, Takara, Nakamura, Naotoshi, Fujita, Yasuhisa, Nakaoka, Shinji, Aihara, Kazuyuki, Perelson, Alan S., Allweiss, Lena, Dandri, Maura, Watashi, Koichi, Tanaka, Yasuhito, Iwami, Shingo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.03.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Antigens; Antiviral Agents - therapeutic use; B cells; BASIC BIOLOGICAL SCIENCES; Biological Science; Biology and Life Sciences; Biomarkers; Biopsy; Cell culture; Chronic infection; Circular DNA; Datasets; Deoxyribonucleic acid; Differential equations; DNA; DNA, Circular; DNA, Viral - genetics; Experiments; Health aspects; Hepatitis; Hepatitis B; Hepatitis B - drug therapy; Hepatitis B - pathology; Hepatitis B e antigen; Hepatitis B e Antigens - genetics; Hepatitis B surface antigen; Hepatitis B Surface Antigens - genetics; Hepatitis B virus; Hepatitis B virus - genetics; Hepatocytes; Humans; In vivo methods and tests; Infection; Infections; Liver; Liver - pathology; Mathematical models; Medicine and Health Sciences; Ordinary differential equations; Partial differential equations; Peripheral blood; Pharmacology; Proteins; Research and Analysis Methods; Viral infections; Japan

Chronic infection with hepatitis B virus (HBV) is caused by the persistence of closed circular DNA (cccDNA) in the nucleus of infected hepatocytes. Despite available therapeutic anti-HBV agents, eliminating the cccDNA remains challenging. Thus, quantifying and understanding the dynamics of cccDNA ar...