Modulation of Oxidative Stress and Melanogenesis by Proanthocyanidins

• Published in: Biological & Pharmaceutical Bulletin Vol. 32; no. 7; pp. 1155 - 1159
• Main Authors: Kim, You Jung, Yokozawa, Takako
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.07.2009; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Animals; Cell Line, Tumor; Cell Survival - drug effects; Diospyros - chemistry; flavonoid; Glutathione - metabolism; Lipid Peroxidation - drug effects; Melanins - biosynthesis; melanogenesis; Mice; Monophenol Monooxygenase - metabolism; oxidative stress; Oxidative Stress - drug effects; proanthocyanidin; Proanthocyanidins - isolation & purification; Proanthocyanidins - pharmacology; Reactive Nitrogen Species - metabolism; Reactive Oxygen Species - metabolism; redox balance

Proanthocyanidins (PAs) are polymer chains of flavonoids known to have a high free radical scavenging capacity. However, their efficacy for use in dermatological health has not been fully explored. In the present study, we investigated the inhibitory property of PAs on melanogenesis and oxidative st...