Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome - De Felice, Claudio; Della Ragione, Floriana; Signorini, Cinzia; Leoncini, Silvia; Pecorelli, Alessandra; Ciccoli, Lucia; Scalabrì, Francesco; Marracino, Federico; Madonna, Michele; Belmonte, Giuseppe; Ricceri, Laura; De Filippis, Bianca; et al. (Neurobiology of disease, 2014)
Keywords: Aldehydes - metabolism; Analysis of Variance; Animals; Arachidonic Acid - metabolism; Biochemistry, Molecular Biology; Brain damage; Brain Injuries - blood; Brain Injuries - etiology; Brain Injuries - pathology; Disease Models, Animal; Docosahexaenoic Acids - metabolism; Female; Gas Chromatography-Mass Spectrometry; Genomics; Isoprostanes - metabolism; Life Sciences; Lipid peroxidation; Male; Methyl-CpG-Binding Protein 2 - genetics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Murine models; Mutation - genetics; Nestin - genetics; Neurobiology; Neurodevelopmental disorder; Neurology; Neurons and Cognition; Neuroprostanes - metabolism; Oxidative stress; Oxidative Stress - physiology; Rett syndrome; Rett Syndrome - blood; Rett Syndrome - complications; Rett Syndrome - genetics; Oxidative stress; Mecp2 308/x; Mecp2 308/y; Lipid peroxidation; F4-NeuroPs; Neurodevelopmental disorder; wt-Cre; MECP2; Mecp2 stop/y NestinCre; RTT; 4-HNE; 4-HNE PAs; wt; AdA; OS; BDNF; F2-IsoPs; Mecp2 stop/y; Mecp2 −/y; NPBI; F2-dihomo-IsoPs; ARA; IsoPs; PSV; Murine models; CRE; ROS; Rett syndrome; Brain damage; DHA; PUFAs; ASDs; AUs; adrenic acid; methyl-CpG-binding protein 2 — mouse gene; 4-hydroxy-2-nonenal protein adducts; Lox/stop pre-symptomatic hemizygous mice; methyl-CpG-binding protein 2 — human protein; autism spectrum disorders; brain-derived neurotrophic factor; arachidonic acid; symptomatic Mecp2 308-mutated hemizygous males; F 2-dihomo-isoprostanes; F 2-isoprostanes; 4-HNE protein adducts; wild type; methyl-CpG-binding protein 2 — mouse protein; Preserved Speech Variant; arbitrary units; polyunsaturated fatty acids; F 4-neuroprostanes; F 2-IsoPs; isoprostanes; docosahexaenoic acid; reactive oxygen species; 4-hydroxy-2-nonenal; non-protein-bound iron; hemizygous null mice; wild type expressing Cre recombinase; F 2-dihomo-IsoPs; symptomatic Mecp2 308-mutated females; methyl-CpG-binding protein 2 — human gene; Cre-Recombinase; rescued Lox/stop mice ( Mecp2 reactivated in the nervous tissue)