Rhipicephalus microplus and Ixodes ovatus cystatins in tick blood digestion and evasion of host immune response

• Published in: Parasites & vectors Vol. 8; no. 1; p. 122
• Main Authors: Parizi, Luís Fernando, Sabadin, Gabriela Alves, Alzugaray, María Fernanda, Seixas, Adriana, Logullo, Carlos, Konnai, Satoru, Ohashi, Kazuhiko, Masuda, Aoi, da Silva Vaz Jr, Itabajara
• Format: Journal Article
• Language: English
• Published: England Springer-Verlag 24.02.2015; BioMed Central Ltd; BioMed Central; BMC
• Subjects: Amino Acid Sequence; Analysis; Animals; Antibodies; Antigens; Blood; blood serum; Boophilus microplus; Cathepsins; control methods; Cricetinae; Cross Reactions; Cystatin; cystatins; Cystatins - immunology; Cysteine; Cystine; Digestion; eggs; enzyme inhibition; Female; females; Health aspects; Host-Parasite Interactions; human health; Humans; Immune response; immunization; Immunization - veterinary; Inhibitor; Ixodes; Ixodes - genetics; Ixodes - immunology; Ixodes - physiology; Ixodes ovatus; larval development; Livestock; Male; Molecular Sequence Data; Phylogeny; Physiological aspects; Protease inhibitors; Proteins; Proteolysis; Rabbits; Recombinant Proteins; research and development; Rhipicephalus - genetics; Rhipicephalus - immunology; Rhipicephalus - physiology; Rhipicephalus microplus; saliva; secretion; Sequence Alignment; Tick; ticks; vaccines; Viral antibodies

BACKGROUND: Cystatins are a group of cysteine protease inhibitors responsible for physiological proteolysis regulation and present in a wide range of organisms. Studies about this class of inhibitors in parasites have contributed to clarify their roles in important physiological processes, like bloo...