Hepatitis B Virus Reactivation After Switch to Cabotegravir/Rilpivirine in Patient with Low Hepatitis B Surface Antibody
A patient in Japan with HIV began antiretroviral therapy because of acute hepatitis B virus (HBV) 15 years ago, with low hepatitis B surface antibody, and experienced breakthrough HBV reactivation 4 months after switching from bictegravir/emtricitabine/tenofovir alafenamide to cabotegravir/rilpiviri...
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| Published in | Emerging infectious diseases Vol. 30; no. 8; pp. 1668 - 1671 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
U.S. National Center for Infectious Diseases
01.08.2024
Centers for Disease Control and Prevention |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A patient in Japan with HIV began antiretroviral therapy because of acute hepatitis B virus (HBV) 15 years ago, with low hepatitis B surface antibody, and experienced breakthrough HBV reactivation 4 months after switching from bictegravir/emtricitabine/tenofovir alafenamide to cabotegravir/rilpivirine. An immune escape mutation, E164V, was identified in the isolated HBV DNA. |
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| AbstractList | A patient in Japan with HIV began antiretroviral therapy because of acute hepatitis B virus (HBV) 15 years ago, with low hepatitis B surface antibody, and experienced breakthrough HBV reactivation 4 months after switching from bictegravir/emtricitabine/tenofovir alafenamide to cabotegravir/rilpivirine. An immune escape mutation, E164V, was identified in the isolated HBV DNA. A patient in Japan with HIV began antiretroviral therapy because of acute hepatitis B virus (HBV) 15 years ago, with low hepatitis B surface antibody, and experienced breakthrough HBV reactivation 4 months after switching from bictegravir/emtricitabine/tenofovir alafenamide to cabotegravir/rilpivirine. An immune escape mutation, E164V, was identified in the isolated HBV DNA.A patient in Japan with HIV began antiretroviral therapy because of acute hepatitis B virus (HBV) 15 years ago, with low hepatitis B surface antibody, and experienced breakthrough HBV reactivation 4 months after switching from bictegravir/emtricitabine/tenofovir alafenamide to cabotegravir/rilpivirine. An immune escape mutation, E164V, was identified in the isolated HBV DNA. |
| Audience | Professional Academic |
| Author | Kanno, Yoshiaki Koga, Michiko Yotsuyanagi, Hiroshi Adachi, Eisuke Takahashi, Kazuaki Saito, Makoto Otani, Amato Arizono, Kotaro Sedohara, Ayako |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39043430$$D View this record in MEDLINE/PubMed |
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| Keywords | viruses HIV hepatitis B HBV reactivation Japan antiretroviral therapy hepatitis B virus vaccine-escape mutation cabotegravir HBV rilpivirine |
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| SubjectTerms | Acquired immune deficiency syndrome AIDS Anti-HIV agents Anti-HIV Agents - therapeutic use Antibodies Antigens Antiretroviral agents Antiretroviral drugs antiretroviral therapy Antiviral agents B cells cabotegravir Case studies Complications and side effects Diketopiperazines Disease control Dispatch Drug therapy Drugs Enzymes HBV Hepatitis Hepatitis B Hepatitis B - drug therapy Hepatitis B - virology Hepatitis B Antibodies - blood Hepatitis B Antibodies - immunology Hepatitis B Surface Antigens - blood Hepatitis B Surface Antigens - immunology Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B Virus Reactivation after Switch to Cabotegravir/Rilpivirine in Patient with Low Hepatitis B Surface Antibody Highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - virology HIV patients Humans Infections Infectious diseases Liver Male Middle Aged Mutation Patients Prevention Pyridones - therapeutic use Pyrimidines - therapeutic use Rilpivirine Risk factors Vaccination Vaccines Viral antibodies Virus Activation |
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| Title | Hepatitis B Virus Reactivation After Switch to Cabotegravir/Rilpivirine in Patient with Low Hepatitis B Surface Antibody |
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