Docosahexaenoic Acid Induces Adipose Differentiation-Related Protein through Activation of Retinoid X Receptor in Human Choriocarcinoma BeWo Cells

• Published in: Biological & Pharmaceutical Bulletin Vol. 32; no. 7; pp. 1177 - 1182
• Main Authors: Suzuki, Kazushige, Takahashi, Katsuhiko, Nishimaki-Mogami, Tomoko, Kagechika, Hiroyuki, Yamamoto, Matsuo, Itabe, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.07.2009; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: adipose differentiation-related protein; BeWo cell; Cell Line, Tumor; docosahexaenoic acid; Docosahexaenoic Acids - pharmacology; Humans; Immunoblotting; lipid droplet; Membrane Proteins - agonists; Membrane Proteins - biosynthesis; Microscopy, Fluorescence; Oleic Acid - pharmacology; Perilipin-2; peroxisome proliferator-activated receptor-γ; PPAR gamma - antagonists & inhibitors; PPAR gamma - metabolism; retinoid X receptor; Retinoid X Receptors - antagonists & inhibitors; Retinoid X Receptors - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Triglycerides - metabolism; Trophoblasts - drug effects; Trophoblasts - metabolism

Adipose differentiation-related protein (ADRP) is associated with intracellular lipid droplets that accumulate neutral lipids. Here we report that ADRP expression in a human choriocarcinoma cell line, BeWo, is regulated through activation of retinoid X receptor (RXR) and peroxisome proliferator-acti...