A lab-on-a-chip for hypoxic patch clamp measurements combined with optical tweezers and spectroscopy- first investigations of single biological cells

• Published in: Biomedical engineering online Vol. 14; no. 1; p. 36
• Main Authors: Alrifaiy, Ahmed, Borg, Johan, Lindahl, Olof A, Ramser, Kerstin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.04.2015; BioMed Central
• Subjects: Absorption spectroscopy; Animals; Cell Hypoxia; Centre - Centre for Biomedical Engineering and Physics (CMTF); Centrumbildning - Centrum för medicinsk teknik och fysik (CMTF); Chickens; Erythrocytes - chemistry; Experimental Mechanics; Experimentell mekanik; Fiber Optic Technology - instrumentation; Fysiologi och anatomi; Hypoxia; Industrial Electronics; Industriell elektronik; Integrated circuits; Investigations; Lab-On-A-Chip Devices; Microfluidic system; Microfluidics; Optical Tweezers; Oximetry - instrumentation; Oximetry - methods; Oxygen - blood; Oxygen sensor; Patch clamp; Patch-Clamp Techniques - instrumentation; Physiology and Anatomy; Samhällsfarmaci och klinisk farmaci; Semiconductor chips; Single-Cell Analysis - instrumentation; Single-Cell Analysis - methods; Social and Clinical Pharmacy; Software; Spectrophotometry - instrumentation; Spectrum analysis; Germany

The response and the reaction of the brain system to hypoxia is a vital research subject that requires special instrumentation. With this research subject in focus, a new multifunctional lab-on-a-chip (LOC) system with control over the oxygen content for studies on biological cells was developed. Th...