Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function

• Published in: Thrombosis and haemostasis Vol. 100; no. 6; p. 1136
• Main Authors: Gori, Anna Maria, Marcucci, Rossella, Paniccia, Rita, Giusti, Betti, Fedi, Sandra, Antonucci, Emilia, Buonamici, Piergiovanni, Antoniucci, David, Gensini, Gian Franco, Abbate, Rosanna
• Format: Journal Article
• Language: English
• Published: Germany 01.12.2008
• Subjects: Adenosine Diphosphate; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary - adverse effects; Angioplasty, Balloon, Coronary - instrumentation; Arachidonic Acid; Aspirin - therapeutic use; Collagen - metabolism; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Likelihood Functions; Male; Middle Aged; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - therapeutic use; Platelet Function Tests - instrumentation; Platelet Function Tests - methods; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Thrombosis - blood; Thrombosis - diagnosis; Thrombosis - etiology; Thrombosis - prevention & control; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use

A higher rate of clinical events in poor clopidogrel and/or aspirin responders was documented by using different methods to measure platelet function, but no conclusive data about the appropriate methodology to explore platelet reactivity are available. A total of 746 patients included in the cohort...