Regulation of microRNA biogenesis and function

• Published in: Thrombosis and haemostasis Vol. 107; no. 4; p. 605
• Main Authors: Treiber, T, Treiber, N, Meister, G
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2012
• Subjects: 3' Untranslated Regions; Animals; Argonaute Proteins - metabolism; DEAD-box RNA Helicases - metabolism; Gene Expression; Gene Expression Regulation; Gene Silencing; Humans; MicroRNAs - metabolism; Models, Biological; Neoplasms - genetics; Nucleotides - metabolism; Phosphorylation; Ribonuclease III - metabolism

MicroRNAs (miRNAs) are considered as key regulators of literally all cellular pathways. Therefore, miRNA biosynthesis and their individual cellular functions must be tightly regulated as well. MiRNAs are transcribed as primary transcripts, which are processed to mature miRNAs in two consecutive matu...