IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells

• Published in: Journal of allergy and clinical immunology Vol. 138; no. 5; pp. 1356 - 1366
• Main Authors: Galand, Claire, Leyva-Castillo, Juan Manuel, Yoon, Juhan, Han, Alex, Lee, Margaret S., McKenzie, Andrew N.J., Stassen, Michael, Oyoshi, Michiko K., Finkelman, Fred D., Geha, Raif S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016; Elsevier Limited
• Subjects: Administration, Cutaneous; Allergens - immunology; Allergy and Immunology; Anaphylaxis - immunology; Animals; Antigens; atopic dermatitis; Cytokines; Dermatitis, Atopic - immunology; Female; Food; Food allergies; food allergy; Food Hypersensitivity - immunology; Gene expression; Human subjects; Humans; IL-33; Immunoglobulin E - immunology; Interleukin-33 - genetics; Interleukin-33 - immunology; Kinases; mast cells; Mast Cells - immunology; Mice, Inbred BALB C; Mice, Transgenic; Ovalbumin - immunology; Proteins; RNA, Messenger - metabolism; Rodents; Skin - immunology; ST2; AD; TSLP; DNP; atopic dermatitis; mast cells; IL-33; food allergy; mMCP-1; ST2; DNP-HSA; LAMP-1; MC; TNP; sLAMP-1; OVA; TNP-BSA; IL-33R; WT; BMMC; Lysosomal-associated membrane protein 1; Trinitrophenyl; Ovalbumin; Bone marrow–derived mast cell; Trinitrophenyl-conjugated BSA; Dinitrophenyl-conjugated human serum albumin; Wild-type; Thymic stromal lymphopoietin; Mouse mast cell protease 1; Dinitrophenyl; Surface LAMP-1; Mast cell; IL-33 receptor

Cutaneous exposure to food allergens predisposes to food allergy, which is commonly associated with atopic dermatitis (AD). Levels of the epithelial cytokine IL-33 are increased in skin lesions and serum of patients with AD. Mast cells (MCs) play a critical role in food-induced anaphylaxis and expre...