Frustration in biomolecules

• Published in: Quarterly reviews of biophysics Vol. 47; no. 4; pp. 285 - 363
• Main Authors: Ferreiro, Diego U., Komives, Elizabeth A., Wolynes, Peter G.
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.11.2014
• Subjects: Biochemistry - methods; Biomolecules; Biopolymers - chemistry; Biopolymers - metabolism; Condensed matter; Dynamical systems; Dynamics; Frustration; Humans; Magnetic Phenomena; Mathematical analysis; Mathematical models; Movement; Proteins; Thermodynamics

Biomolecules are the prime information processing elements of living matter. Most of these inanimate systems are polymers that compute their own structures and dynamics using as input seemingly random character strings of their sequence, following which they coalesce and perform integrated cellular...