Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

• Published in: Science (American Association for the Advancement of Science) Vol. 365; no. 6460; p. 1417
• Main Authors: Patsopoulos, Nikolaos A., Baranzini, Sergio E., Santaniello, Adam, Shoostari, Parisa, Cotsapas, Chris, Wong, Garrett, Beecham, Ashley H., James, Tojo, Replogle, Joseph, Vlachos, Ioannis S., McCabe, Cristin, Pers, Tune H., Brandes, Aaron, White, Charles, Keenan, Brendan, Cimpean, Maria, Winn, Phoebe, Panteliadis, Ioannis-Pavlos, Robbins, Allison, Andlauer, Till F. M., Zarzycki, Onigiusz, Dubois, Bénédicte, Goris, An, Søndergaard, Helle Bach, Sellebjerg, Finn, Sorensen, Per Soelberg, Ullum, Henrik, Thørner, Lise Wegner, Saarela, Janna, Cournu-Rebeix, Isabelle, Damotte, Vincent, Fontaine, Bertrand, Guillot-Noel, Lena, Lathrop, Mark, Vukusic, Sandra, Berthele, Achim, Pongratz, Viola, Buck, Dorothea, Gasperi, Christiane, Graetz, Christiane, Grummel, Verena, Hemmer, Bernhard, Hoshi, Muni, Knier, Benjamin, Korn, Thomas, Lill, Christina M., Luessi, Felix, Mühlau, Mark, Zipp, Frauke, Dardiotis, Efthimios, Agliardi, Cristina, Amoroso, Antonio, Barizzone, Nadia, Benedetti, Maria D., Bernardinelli, Luisa, Cavalla, Paola, Clarelli, Ferdinando, Comi, Giancarlo, Cusi, Daniele, Esposito, Federica, Ferrè, Laura, Galimberti, Daniela, Guaschino, Clara, Leone, Maurizio A., Martinelli, Vittorio, Moiola, Lucia, Salvetti, Marco, Sorosina, Melissa, Vecchio, Domizia, Zauli, Andrea, Santoro, Silvia, Mancini, Nicasio, Zuccalà, Miriam, Mescheriakova, Julia, van Duijn, Cornelia, Bos, Steffan D., Celius, Elisabeth G., Spurkland, Anne, Comabella, Manuel, Montalban, Xavier, Alfredsson, Lars, Bomfim, Izaura L., Gomez-Cabrero, David, Hillert, Jan, Jagodic, Maja, Lindén, Magdalena, Piehl, Fredrik, Jelčić, Ilijas, Martin, Roland, Sospedra, Mirela, Baker, Amie, Ban, Maria, Hawkins, Clive, Hysi, Pirro, Kalra, Seema, Karpe, Fredrik, Khadake, Jyoti, Lachance, Genevieve, Molyneux, Paul, Neville, Matthew
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 27.09.2019; The American Association for the Advancement of Science; American Association for the Advancement of Science (AAAS)
• Subjects: Adaptive systems; Anatomy; Annotations; Architecture; Astrocytes; Autoimmune diseases; Brain; Case-Control Studies; Cell Cycle Proteins - genetics; Central nervous system; Chromosome Mapping; Chromosomes; Chromosomes, Human, X - genetics; Consortia; Data analysis; Enrichment; Gene expression; Gene Frequency; Gene mapping; Genes; Genetic Loci; Genetics; Genome-Wide Association Study; Genomes; Genomics; Genotypes; GTPase-Activating Proteins - genetics; Heritability; Human health and pathology; Humans; Immune system; Individualized Instruction; Inheritance Patterns; Life Sciences; Loci; Lymphocytes; Lymphocytes B; Lymphocytes T; Major Histocompatibility Complex; Microglia; Microglia - immunology; Multiple sclerosis; Multiple Sclerosis - genetics; Myeloid cells; Natural killer cells; Nervous system; Neurons; Perturbation; Pluripotency; Polymorphism, Single Nucleotide; Prevention; Protein interaction; Proteins; Quantitative Trait Loci; Replication; RESEARCH ARTICLE SUMMARY; Risk; RNA-Seq; Statistical Significance; Statistics; Stem cells; Transcriptome; Young adults

The genetics underlying who develops multiple sclerosis (MS) have been difficult to work out. Examining more than 47,000 cases and 68,000 controls with multiple genome-wide association studies, the International Multiple Sclerosis Genetics Consortium identified more than 200 risk loci in MS (see the...