Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility - Patsopoulos, Nikolaos A.; Baranzini, Sergio E.; Santaniello, Adam; Shoostari, Parisa; Cotsapas, Chris; Wong, Garrett; Beecham, Ashley H.; James, Tojo; Replogle, Joseph; Vlachos, Ioannis S.; McCabe, Cristin; Pers, Tune H.; et al. (Science (American Association for the Advancement of Science), 2019)
Keywords: Adaptive systems; Anatomy; Annotations; Architecture; Astrocytes; Autoimmune diseases; Brain; Case-Control Studies; Cell Cycle Proteins - genetics; Central nervous system; Chromosome Mapping; Chromosomes; Chromosomes, Human, X - genetics; Consortia; Data analysis; Enrichment; Gene expression; Gene Frequency; Gene mapping; Genes; Genetic Loci; Genetics; Genome-Wide Association Study; Genomes; Genomics; Genotypes; GTPase-Activating Proteins - genetics; Heritability; Human health and pathology; Humans; Immune system; Individualized Instruction; Inheritance Patterns; Life Sciences; Loci; Lymphocytes; Lymphocytes B; Lymphocytes T; Major Histocompatibility Complex; Microglia; Microglia - immunology; Multiple sclerosis; Multiple Sclerosis - genetics; Myeloid cells; Natural killer cells; Nervous system; Neurons; Perturbation; Pluripotency; Polymorphism, Single Nucleotide; Prevention; Protein interaction; Proteins; Quantitative Trait Loci; Replication; RESEARCH ARTICLE SUMMARY; Risk; RNA-Seq; Statistical Significance; Statistics; Stem cells; Transcriptome; Young adults