Endotheliopathy and Platelet Dysfunction as Hallmarks of Fatal Lassa Fever

• Published in: Emerging infectious diseases Vol. 26; no. 11; pp. 2625 - 2637
• Main Authors: Horton, Lucy E., Cross, Robert W., Hartnett, Jessica N., Engel, Emily J., Sakabe, Saori, Goba, Augustine, Momoh, Mambu, Sandi, John Demby, Geisbert, Thomas W., Garry, Robert F., Schieffelin, John S., Grant, Donald S., Sullivan, Brian M.
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.11.2020; Centers for Disease Control and Prevention
• Subjects: Adolescent; Adult; Aged; Antigens; Ascites; Blood Coagulation; Blood platelets; Blood Platelets - pathology; Causes of; Child; Child, Preschool; coagulation; Development and progression; Diagnosis; Disease; Edema; Endotheliopathy and Platelet Dysfunction as Hallmarks of Fatal Lassa Fever; Endothelium; Endothelium - physiopathology; Enzymes; Fatalities; Female; Fever; Fibrinolysis; Health aspects; Health care; hemostasis; Humans; Infant; Laboratories; Lassa fever; Lassa Fever - diagnosis; Lassa Fever - epidemiology; Male; Middle Aged; Molecular weight; Permeability; Plasma; platelet; Platelet function disorders; protein C; Proteins; R&D; Research & development; Sepsis; Sierra Leone; Software; Thrombocytopenia; Tropical diseases; Young Adult; Sierra Leone; fibrinolysis; Lassa fever; viruses; vector-borne infections; hemorrhagic fever; platelet; zoonoses; hemostasis; protein C; coagulation

Lassa fever (LF) causes multisystem disease and has a fatality rate <70%. Severe cases exhibit abnormal coagulation, endothelial barrier disruption, and dysfunctional platelet aggregation but the underlying mechanisms remain poorly understood. In Sierra Leone during 2015-2018, we assessed LF pati...