A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence

• Published in: PLoS pathogens Vol. 18; no. 5; p. e1010488
• Main Authors: Welbourn, Sarah, Chakraborty, Srirupa, Yang, Jie E, Gleinich, Anne S, Gangadhara, Sailaja, Khan, Salar, Ferrebee, Courtney, Yagnik, Bhrugu, Burton, Samantha, Charles, Tysheena, Smith, S Abigail, Williams, Danielle, Mopuri, Rohini, Upadhyay, Amit A, Thompson, Justin, Price, Matt A, Wang, Shiyu, Qin, Zhaohui, Shen, Xiaoying, Williams, LaTonya D, Eisel, Nathan, Peters, Tiffany, Zhang, Lu, Kilembe, William, Karita, Etienne, Tomaras, Georgia D, Bosinger, Steven E, Amara, Rama R, Azadi, Parastoo, Wright, Elizabeth R, Gnanakaran, Sandrasegaram, Derdeyn, Cynthia A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.05.2022; Public Library of Science (PLoS)
• Subjects: AIDS Vaccines; Amino acids; Animals; Antibodies; Antibodies, Neutralizing; Antigens; BASIC BIOLOGICAL SCIENCES; Binding sites; Biology and life sciences; Care and treatment; Chemical bonds; Computer applications; Deoxyribonucleic acid; Development and progression; DNA; env Gene Products, Human Immunodeficiency Virus; Genetic aspects; Glycan; Glycoprotein gp120; Health aspects; HIV; HIV Antibodies; HIV Envelope Protein gp120; HIV infection; HIV Infections - prevention & control; HIV-1; Human immunodeficiency virus; Humans; Immune response; Immunization; Immunogenicity; Immunoglobulin G; Infections; Macaca mulatta; Medicine and health sciences; Monoclonal antibodies; Neutralization; Neutralizing; Plasma; Process controls; Proteins; Research and Analysis Methods; Vaccination; Vaccines; Viral proteins; Virus research; United States; Zambia

Transmitted/founder (T/F) HIV-1 envelope proteins (Envs) from infected individuals that developed neutralization breadth are likely to possess inherent features desirable for vaccine immunogen design. To explore this premise, we conducted an immunization study in rhesus macaques (RM) using T/F Env s...