Morphologic Analysis of M2 Macrophage in Glioblastoma: Involvement of Macrophage Extracellular Traps (METs)
Macrophages are classified into two phenotypes, M1 and M2, based on their roles. M2 macrophages suppress inflammation and increase in proportion to the malignancy of brain tumors. Recently, macrophage extracellular traps (METs), which change into a network, have been reported as a unique form of mac...
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| Published in | ACTA HISTOCHEMICA ET CYTOCHEMICA Vol. 55; no. 4; pp. 111 - 118 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Japan
JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY
27.08.2022
Japan Science and Technology Agency |
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| Abstract | Macrophages are classified into two phenotypes, M1 and M2, based on their roles. M2 macrophages suppress inflammation and increase in proportion to the malignancy of brain tumors. Recently, macrophage extracellular traps (METs), which change into a network, have been reported as a unique form of macrophage cell death. In this study, immunohistochemical analysis of macrophages in METs in human glioblastoma was performed. To distinguish between M1 and M2 macrophages, multiple immunostainings with Iba1 combined with CD163 or CD204 were performed. M2 macrophages were present in small amounts in normal and borderline areas but showed an increasing trend as they shifted to tumor areas, and most of them were the activated- or phagocytic-type. We also successfully detected METs coexisting with fibrin and lactoferrin near the border between the tumor and necrotic area. M2 macrophages not only suppressed inflammation but also were involved in the formation of METs. This study found that M2 macrophages play various roles in unstable situations. |
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| AbstractList | Macrophages are classified into two phenotypes, M1 and M2, based on their roles. M2 macrophages suppress inflammation and increase in proportion to the malignancy of brain tumors. Recently, macrophage extracellular traps (METs), which change into a network, have been reported as a unique form of macrophage cell death. In this study, immunohistochemical analysis of macrophages in METs in human glioblastoma was performed. To distinguish between M1 and M2 macrophages, multiple immunostainings with Iba1 combined with CD163 or CD204 were performed. M2 macrophages were present in small amounts in normal and borderline areas but showed an increasing trend as they shifted to tumor areas, and most of them were the activated- or phagocytic-type. We also successfully detected METs coexisting with fibrin and lactoferrin near the border between the tumor and necrotic area. M2 macrophages not only suppressed inflammation but also were involved in the formation of METs. This study found that M2 macrophages play various roles in unstable situations. Macrophages are classified into two phenotypes, M1 and M2, based on their roles. M2 macrophages suppress inflammation and increase in proportion to the malignancy of brain tumors. Recently, macrophage extracellular traps (METs), which change into a network, have been reported as a unique form of macrophage cell death. In this study, immunohistochemical analysis of macrophages in METs in human glioblastoma was performed. To distinguish between M1 and M2 macrophages, multiple immunostainings with Iba1 combined with CD163 or CD204 were performed. M2 macrophages were present in small amounts in normal and borderline areas but showed an increasing trend as they shifted to tumor areas, and most of them were the activated- or phagocytic-type. We also successfully detected METs coexisting with fibrin and lactoferrin near the border between the tumor and necrotic area. M2 macrophages not only suppressed inflammation but also were involved in the formation of METs. This study found that M2 macrophages play various roles in unstable situations.Macrophages are classified into two phenotypes, M1 and M2, based on their roles. M2 macrophages suppress inflammation and increase in proportion to the malignancy of brain tumors. Recently, macrophage extracellular traps (METs), which change into a network, have been reported as a unique form of macrophage cell death. In this study, immunohistochemical analysis of macrophages in METs in human glioblastoma was performed. To distinguish between M1 and M2 macrophages, multiple immunostainings with Iba1 combined with CD163 or CD204 were performed. M2 macrophages were present in small amounts in normal and borderline areas but showed an increasing trend as they shifted to tumor areas, and most of them were the activated- or phagocytic-type. We also successfully detected METs coexisting with fibrin and lactoferrin near the border between the tumor and necrotic area. M2 macrophages not only suppressed inflammation but also were involved in the formation of METs. This study found that M2 macrophages play various roles in unstable situations. |
| ArticleNumber | 22-00018 |
| Author | Michiba, Ayano Tsukamoto, Tetsuya Yamada, Seiji Shiogama, Kazuya Abe, Masato Hirayama, Masaya |
| Author_xml | – sequence: 1 fullname: Yamada, Seiji organization: Department of Diagnostic Pathology, Fujita Health University Graduate School of Medicine – sequence: 1 fullname: Shiogama, Kazuya organization: Department of Morphology and Pathology, Fujita Health University Medical Science – sequence: 1 fullname: Abe, Masato organization: Department of Morphology and Pathology, Fujita Health University Medical Science – sequence: 1 fullname: Hirayama, Masaya organization: Department of Morphology and Pathology, Fujita Health University Medical Science – sequence: 1 fullname: Michiba, Ayano organization: Department of Diagnostic Pathology, Fujita Health University Graduate School of Medicine – sequence: 1 fullname: Tsukamoto, Tetsuya organization: Department of Diagnostic Pathology, Fujita Health University Graduate School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36060293$$D View this record in MEDLINE/PubMed |
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| Keywords | macrophage extracellular traps (METs) glioblastoma M1 and M2 macrophage microglia |
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| References_xml | – reference: 11 Hagemann, T., Lawrence, T., McNeish, I., Charles, K. A., Kulbe, H., Thompson, R. G., et al. (2008) “Re-educating” tumor-associated macrophages by targeting NF-kappaB. J. Exp. Med. 205; 1261–1268. – reference: 5 Cherry, J. D., Olschowka, J. A. and O’Banion, M. K. (2014) Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J. Neuroinflammation 11; 98. – reference: 30 Sasaki, A. (2017) Microglia and brain macrophages: An update. Neuropathology 37; 452–464. – reference: 37 Xu, S. S., Li, H., Li, T. J., Li, S., Xia, H. Y., Long, J., et al. (2021) Neutrophil Extracellular Traps and Macrophage Extracellular Traps Predict Postoperative Recurrence in Resectable Nonfunctional Pancreatic Neuroendocrine Tumors. Front. Immunol. 12; 577517. – reference: 35 Wong, K. W. and Jacobs, W. R., Jr. (2013) Mycobacterium tuberculosis exploits human interferon γ to stimulate macrophage extracellular trap formation and necrosis. J. Infect. Dis. 208; 109–119. – reference: 19 Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J. and Hill, A. M. (2000) M-1/M-2 macrophages and the Th1/Th2 paradigm. J. Immunol. 164; 6166–6173. – reference: 1 Aulik, N. A., Hellenbrand, K. M. and Czuprynski, C. J. (2012) Mannheimia haemolytica and its leukotoxin cause macrophage extracellular trap formation by bovine macrophages. Infect. Immun. 80; 1923–1933. – reference: 31 Shiogama, K., Onouchi, T., Mizutani, Y., Sakurai, K., Inada, K. and Tsutsumi, Y. (2016) Visualization of Neutrophil Extracellular Traps and Fibrin Meshwork in Human Fibrinopurulent Inflammatory Lesions: I. Light Microscopic Study. Acta Histochem. Cytochem. 49; 109–116. – reference: 6 Coscia, M., Quaglino, E., Iezzi, M., Curcio, C., Pantaleoni, F., Riganti, C., et al. (2010) Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. J. Cell. Mol. Med. 14; 2803–2815. – reference: 18 Martinez, F. O. and Gordon, S. (2014) The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 6; 13. – reference: 36 Wu, A., Wei, J., Kong, L. Y., Wang, Y., Priebe, W., Qiao, W., et al. (2010) Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol. 12; 1113–1125. – reference: 7 Dong, H., Yang, Y., Gao, C., Sun, H., Wang, H., Hong, C., et al. (2020) Lactoferrin-containing immunocomplex mediates antitumor effects by resetting tumor-associated macrophages to M1 phenotype. J. Immunother. Cancer 8; e000339. – reference: 15 Komohara, Y., Ohnishi, K., Kuratsu, J. and Takeya, M. (2008) Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J. Pathol. 216; 15–24. – reference: 20 Mohanan, S., Horibata, S., McElwee, J. L., Dannenberg, A. J. and Coonrod, S. A. (2013) Identification of macrophage extracellular trap-like structures in mammary gland adipose tissue: a preliminary study. Front. 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| SubjectTerms | Brain tumors CD163 antigen Cell death Fibrin Glioblastoma Inflammation Lactoferrin M1 and M2 macrophage macrophage extracellular traps (METs) Macrophages microglia Phagocytes Phenotypes Regular |
| Title | Morphologic Analysis of M2 Macrophage in Glioblastoma: Involvement of Macrophage Extracellular Traps (METs) |
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