Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Zhiming Cai and colleagues report the exome sequencing of tumor and matched normal tissue from nine transitional cell carcinomas (TCCs) of the bladder, with further screening in 88 additional subjects. The authors identify mutations in chromatin remodeling genes in 59% of the 97 TCC subjects. Transi...

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Published inNature genetics Vol. 43; no. 9; pp. 875 - 878
Main Authors Gui, Yaoting, Guo, Guangwu, Huang, Yi, Hu, Xueda, Tang, Aifa, Gao, Shengjie, Wu, Renhua, Chen, Chao, Li, Xianxin, Zhou, Liang, He, Minghui, Li, Zesong, Sun, Xiaojuan, Jia, Wenlong, Chen, Jinnong, Yang, Shangming, Zhou, Fangjian, Zhao, Xiaokun, Wan, Shengqing, Ye, Rui, Liang, Chaozhao, Liu, Zhisheng, Huang, Peide, Liu, Chunxiao, Jiang, Hui, Wang, Yong, Zheng, Hancheng, Sun, Liang, Liu, Xingwang, Jiang, Zhimao, Feng, Dafei, Chen, Jing, Wu, Song, Zou, Jing, Zhang, Zhongfu, Yang, Ruilin, Zhao, Jun, Xu, Congjie, Yin, Weihua, Guan, Zhichen, Ye, Jiongxian, Zhang, Hong, Li, Jingxiang, Kristiansen, Karsten, Nickerson, Michael L, Theodorescu, Dan, Li, Yingrui, Zhang, Xiuqing, Li, Songgang, Wang, Jian, Yang, Huanming, Wang, Jun, Cai, Zhiming
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.09.2011
Nature Publishing Group
Subjects
631/208/2489/144/68
631/337/100/102
692/699/67/589/1336
Adenocarcinoma
Agriculture
Animal Genetics and Genomics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Carcinoma, Transitional Cell - genetics
Chromatin Assembly and Disassembly - genetics
Chromosome Aberrations
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Neoplastic
Gene Function
Gene mutations
Genes
Genetic aspects
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Human
Human Genetics
Humans
letter
Mutation
Polymerase chain reaction
Urinary Bladder Neoplasms - genetics
United States
China
Human
Exon
Urinary system
Nucleotide sequence
Urinary bladder
Malignant tumor
Transitional cell carcinoma
Mutation
Cancer
Chromatin remodeling
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Abstract Zhiming Cai and colleagues report the exome sequencing of tumor and matched normal tissue from nine transitional cell carcinomas (TCCs) of the bladder, with further screening in 88 additional subjects. The authors identify mutations in chromatin remodeling genes in 59% of the 97 TCC subjects. Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes ( UTX, MLL - MLL3 , CREBBP - EP300 , NCOR1 , ARID1A and CHD6 ) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
AbstractList Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer. [PUBLICATION ABSTRACT]
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes ( UTX, MLL - MLL3 , CREBBP-EP300 , NCOR1 , ARID1A and CHD6 ) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBPEP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
Zhiming Cai and colleagues report the exome sequencing of tumor and matched normal tissue from nine transitional cell carcinomas (TCCs) of the bladder, with further screening in 88 additional subjects. The authors identify mutations in chromatin remodeling genes in 59% of the 97 TCC subjects. Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes ( UTX, MLL - MLL3 , CREBBP - EP300 , NCOR1 , ARID1A and CHD6 ) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
Audience Academic
Author Liu, Zhisheng
Li, Songgang
Nickerson, Michael L
Wan, Shengqing
Wang, Yong
Sun, Xiaojuan
Chen, Chao
Zheng, Hancheng
Gao, Shengjie
Sun, Liang
Ye, Rui
Wu, Song
Jia, Wenlong
Liu, Xingwang
Tang, Aifa
Zhang, Zhongfu
Feng, Dafei
Li, Jingxiang
Yang, Huanming
Zhang, Xiuqing
Chen, Jinnong
Li, Xianxin
He, Minghui
Zhou, Liang
Yang, Shangming
Xu, Congjie
Yin, Weihua
Gui, Yaoting
Liang, Chaozhao
Hu, Xueda
Huang, Peide
Li, Zesong
Yang, Ruilin
Theodorescu, Dan
Ye, Jiongxian
Zhao, Jun
Kristiansen, Karsten
Jiang, Zhimao
Guan, Zhichen
Cai, Zhiming
Wang, Jian
Guo, Guangwu
Zhou, Fangjian
Jiang, Hui
Zhang, Hong
Zou, Jing
Huang, Yi
Wu, Renhua
Wang, Jun
Li, Yingrui
Liu, Chunxiao
Zhao, Xiaokun
Chen, Jing
AuthorAffiliation 7 Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
9 Cancer and Inflammation Program, National Cancer Institute, US National Institutes of Health (NIH), Frederick, Maryland, USA
10 Department of Surgery, University of Colorado Comprehensive Cancer Center, Aurora, Colorado, USA
8 Department of Biology, University of Copenhagen, Copenhagen, Denmark
11 Department of Pharmacology, University of Colorado Comprehensive Cancer Center, Aurora, Colorado, USA
6 Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3 Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
4 Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China
2 BGI-Shenzhen, Shenzhen, China
5 Department of Urology, the Second Xiangya Hospital of Central-Southern University, Changsha, China
1 Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Uro
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  email: caizhiming2000@yahoo.com.cn
  organization: Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University
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Keywords Human
Exon
Urinary system
Nucleotide sequence
Urinary bladder
Malignant tumor
Transitional cell carcinoma
Mutation
Cancer
Chromatin remodeling
Language English
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Snippet Zhiming Cai and colleagues report the exome sequencing of tumor and matched normal tissue from nine transitional cell carcinomas (TCCs) of the bladder, with...
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the...
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StartPage 875
SubjectTerms 631/208/2489/144/68
631/337/100/102
692/699/67/589/1336
Adenocarcinoma
Agriculture
Animal Genetics and Genomics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Carcinoma, Transitional Cell - genetics
Chromatin Assembly and Disassembly - genetics
Chromosome Aberrations
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Neoplastic
Gene Function
Gene mutations
Genes
Genetic aspects
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Human
Human Genetics
Humans
letter
Mutation
Polymerase chain reaction
Urinary Bladder Neoplasms - genetics
Title Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
URI https://link.springer.com/article/10.1038/ng.907
https://www.ncbi.nlm.nih.gov/pubmed/21822268
https://www.proquest.com/docview/894124036
https://www.proquest.com/docview/1034815141
https://www.proquest.com/docview/885907562
https://pubmed.ncbi.nlm.nih.gov/PMC5373841
Volume 43
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