Child Abuse, Neural Structure, and Adolescent Psychopathology: A Longitudinal Study

• Published in: Journal of the American Academy of Child and Adolescent Psychiatry Vol. 56; no. 4; pp. 321 - 328.e1
• Main Authors: Busso, Daniel S., McLaughlin, Katie A., Brueck, Stephanie, Peverill, Matthew, Gold, Andrea L., Sheridan, Margaret A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2017; Elsevier BV
• Subjects: Abused children; Adolescent; Adolescents; Adult; Antisocial behavior; Antisocial personality disorder; Anxiety; Anxiety disorders; Anxiety Disorders - diagnostic imaging; Associations; Biological markers; Cerebral Cortex - diagnostic imaging; Child Abuse; Child abuse & neglect; Children; Cortex; Female; Health status; Humans; Internalization; Interviews; Longitudinal Studies; Magnetic Resonance Imaging; Male; Maltreatment; Medical screening; Mental disorders; Mental health; neural structure; Neurobiology; NMR; Nuclear magnetic resonance; Parahippocampal gyrus; Pediatrics; Psychiatric symptoms; Psychiatry; Psychopathology; Sexual abuse; Social behavior; Social Behavior Disorders - diagnostic imaging; Symptoms; Teenagers; Temporal gyrus; Temporal lobe; trauma; Vulnerability; Young Adult; trauma; neural structure; parahippocampal gyrus; child abuse; psychopathology

Child abuse exerts a deleterious impact on a broad array of mental health outcomes. However, the neurobiological mechanisms that mediate this association remain poorly characterized. Here, we use a longitudinal design to prospectively identify neural mediators of the association between child abuse...