Kinetic Aspects of Surfactant-Induced Structural Changes of Proteins－Unsolved Problems of Two-State Model for Protein Denaturation

• Published in: Journal of Oleo Science Vol. 64; no. 11; pp. 1143 - 1158
• Main Authors: Takeda, Kunio, Moriyama, Yoshiko
• Format: Journal Article
• Language: English; Japanese
• Published: Japan Japan Oil Chemists' Society 2015; Japan Science and Technology Agency
• Subjects: Amino Acid Motifs; Animals; Binding; Denaturation; Helicity; Kinetics; Models, Molecular; Multiprotein Complexes - chemistry; Peptides - chemistry; protein; Protein Denaturation; Proteins; Rate constants; Serum Albumin, Bovine - chemistry; Sodium dodecyl sulfate; Sodium Dodecyl Sulfate - chemistry; Surface-Active Agents - chemistry; surfactant; Surfactants; Temperature; Transforms

The kinetic mechanism of surfactant-induced protein denaturation is discussed on the basis of not only stopped-flow kinetic data but also the changes of protein helicities caused by the surfactants and the discontinuous mobility changes of surfactant-protein complexes. For example, the α-helical str...