Polymorphisms of TNF microsatellite marker a and HLA-DR-DQ in diabetes mellitus—a study in 609 Swedish subjects

• Published in: Human Immunology Vol. 67; no. 7; pp. 527 - 534
• Main Authors: Törn, Carina, Hillman, Magnus, Sanjeevi, Carani B., Landin-Olsson, Mona
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2006
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; autoimmunity; Basic Medicine; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 2 - genetics; Gene Frequency; Genetic predisposition; Genotype; HLA-DQ Antigens - genetics; HLA-DR3 Antigen - genetics; HLA-DR4 Antigen - genetics; Humans; Immunologi inom det medicinska området; Immunologi inom det medicinska området (Här ingår: Cell- och immunterapi); Immunology in the medical area; Immunology in the Medical Area (including Cell and Immunotherapy); Linkage Disequilibrium; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Microsatellite Repeats; Middle Aged; Polymorphism, Genetic; risk; Risk Factors; Sweden; Tumor Necrosis Factor-alpha - genetics; Sweden; Genetic predisposition; autoimmunity; risk

We explored the importance of the genetic markers microsatellite TNFa, HLA-DR3-DQ2, and DR4-DQ8 in diabetes mellitus. The studied groups comprised autoimmune type 1 ( n=63), nonautoimmune type 1 ( n=35), latent autoimmune diabetes in adults (LADA; n=54), and nonautoimmune type 2 ( n=340) and these p...