Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1 Deficiency Reduces Leukocyte Infiltration into Adipose Tissue and Favors Fat Deposition

• Published in: The American journal of pathology Vol. 174; no. 3; pp. 1075 - 1083
• Main Authors: Bour, Sandy, Caspar-Bauguil, Sylvie, Iffiú-Soltész, Zsuzsa, Nibbelink, Maryse, Cousin, Béatrice, Miiluniemi, Mari, Salmi, Marko, Stolen, Craig, Jalkanen, Sirpa, Casteilla, Louis, Pénicaud, Luc, Valet, Philippe, Carpéné, Christian
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.03.2009; ASIP; American Society for Investigative Pathology; American Society for Investigative Pathology / Elsevier
• Subjects: Adipose Tissue - pathology; Adipose Tissue - physiology; Amine Oxidase (Copper-Containing) - deficiency; Amine Oxidase (Copper-Containing) - genetics; Animals; Biological and medical sciences; Cell Adhesion Molecules - deficiency; Cell Adhesion Molecules - genetics; Flow Cytometry; Humans; Investigative techniques, diagnostic techniques (general aspects); Leukocytes - physiology; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Monoamine Oxidase - deficiency; Obesity - genetics; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Regular; Semicarbazides - pharmacology; Anatomic pathology; Amine; Adipose tissue; Enzyme; Leukocyte; Deficiency; Oxidase; Fat; Infiltration; Oxidoreductases; Deposition; Vascular Adhesion Protein 1; Amine Oxidase (Copper-Containing)/deficiency/genetics; Semicarbazides/pharmacology; Cell Adhesion Molecules/deficiency/genetics; Humans; Adipose Tissue/pathology/physiology; Transgenic; Inbred C57BL; Knockout; Leukocytes/physiology; Obesity/genetics; Monoamine Oxidase/deficiency; Animals; Flow Cytometry; Mice

Obesity is associated with low-grade inflammation and leukocyte infiltration in white adipose tissue (WAT) and is linked to diabetic complications. Semicarbazide-sensitive amine oxidase, also known as vascular adhesion protein-1 (SSAO/VAP-1), is a membrane protein that is highly expressed in adipocy...