Urinary Mutagenicity, CYP1A2 and NAT2 Activity in Textile Industry Workers

• Published in: Journal of Occupational Health Vol. 46; no. 6; pp. 440 - 447
• Main Authors: Fanlo, Ana, Sinués, Blanca, Mayayo, Esteban, Bernal, Luisa, Soriano, Antonia, Martínez‐Jarreta, Begoña, Martínez‐Ballarín, Enrique
• Format: Journal Article
• Language: Japanese; English
• Published: Australia JAPAN SOCIETY FOR OCCUPATIONAL HEALTH 01.11.2004; John Wiley & Sons, Inc
• Subjects: Adult; Arylamine N-Acetyltransferase - metabolism; Caffeine - metabolism; Caffeine - urine; Cross-Sectional Studies; CYP1A2; Cytochrome P-450 CYP1A2 - metabolism; Humans; Middle Aged; Multivariate Analysis; Mutagens - poisoning; NAT2; Occupational Exposure - adverse effects; Occupational Exposure - analysis; Salmonella typhimurium; Smoking; Textile Industry; Textile workers; Urine mutagenicity

The two major causes of bladder cancer have been recognised to be cigarette smoke and occupational exposure to arylamines. These compounds are present both in tobacco smoke and in the dyes used in textile production. Aromatic amines suffer oxidative metabolism via P450 cytochrome CYP1A2, and detoxif...