Paternal H3K4 methylation is required for minor zygotic gene activation and early mouse embryonic development

• Published in: EMBO reports Vol. 16; no. 7; pp. 803 - 812
• Main Authors: Aoshima, Keisuke, Inoue, Erina, Sawa, Hirofumi, Okada, Yuki
• Format: Journal Article
• Language: English
• Published: London Blackwell Publishing Ltd 01.07.2015; Nature Publishing Group UK; Springer Nature B.V; John Wiley & Sons, Ltd
• Subjects: Animals; Chromatin; DNA methylation; EMBO09; EMBO11; Embryonic Development - genetics; Embryonic growth stage; Enzymes; Epigenesis, Genetic; Fathers; Female; Fertilization - genetics; Fertilization in Vitro; Gene expression; histone methylation; Histones - genetics; Histones - metabolism; K-M mutant; Lysine - metabolism; Male; Methylation; Mice; minor ZGA; Mll3/4; Mutation; Pregnancy; Scientific Report; Scientific Reports; Spermatozoa; Transcriptional Activation; Zygote - physiology; histone methylation; Mll3/4; minor ZGA; K‐M mutant

Epigenetic modifications, such as DNA methylation and histone modifications, are dynamically altered predominantly in paternal pronuclei soon after fertilization. To identify which histone modifications are required for early embryonic development, we utilized histone K‐M mutants, which prevent endo...