Transcutaneous carbon dioxide application suppresses the expression of cancer-associated fibroblasts markers in oral squamous cell carcinoma xenograft mouse model

• Published in: PloS one Vol. 18; no. 8; p. e0290357
• Main Authors: Tadokoro, Yoshiaki, Takeda, Daisuke, Murakami, Aki, Yatagai, Nanae, Saito, Izumi, Arimoto, Satomi, Kakei, Yasumasa, Akashi, Masaya, Hasegawa, Takumi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.08.2023; Public Library of Science (PLoS)
• Subjects: Animals; Anticancer properties; Antitumor activity; Biology and Life Sciences; Cancer; Cancer therapies; Cancer-Associated Fibroblasts; Carbon Dioxide; Carcinoma, Squamous Cell - drug therapy; Care and treatment; Cell growth; Disease Models, Animal; Fibroblasts; Gene expression; Head & neck cancer; Head and neck cancer; Head and Neck Neoplasms; Health aspects; Heterografts; Humans; Hydrogels; Hypoxia; Lymphatic system; Medical prognosis; Medicine and Health Sciences; Metastasis; Mice; Mouth cancer; Mouth Neoplasms - drug therapy; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Physical Sciences; Polymerase chain reaction; Radiation; Research and Analysis Methods; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck; Staining; Stromal cells; Testing; Transforming growth factor-b; Tumor Microenvironment; Tumors; Xenografts; Xenotransplantation; Japan

Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Cancer-associated fibroblasts (CAFs) are the main stromal cells in the tumor microenvironment (TME). As CAFs promote tumor progression and hypoxia in the TME, regulating the conversion of normal fibroblasts (NFs) into CAFs...