The pathogenesis of influenza virus infections: the contributions of virus and host factors

• Published in: Current opinion in immunology Vol. 23; no. 4; pp. 481 - 486
• Main Authors: Fukuyama, Satoshi, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2011
• Subjects: Allergy and Immunology; Animals; Birds - virology; Cytokines - physiology; fever; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - physiology; Host Specificity; Host-Pathogen Interactions - physiology; Humans; Immunity, Innate; Inflammation; influenza; Influenza A virus; Influenza A virus - genetics; Influenza A virus - immunology; Influenza A virus - pathogenicity; Influenza in Birds - virology; Influenza virus; Influenza, Human - epidemiology; Influenza, Human - etiology; Influenza, Human - immunology; Influenza, Human - physiopathology; Influenza, Human - virology; Models, Biological; pandemic; Pandemics; pathogenesis; pneumonia; signs and symptoms (animals and humans); Species Specificity; Toll-Like Receptors - physiology; Viral Proteins - physiology; Virulence; viruses

► The pathogenicity of influenza A virus (IVA) depends on interactions between virus and host proteins. ► Among the viral proteins, HA is responsible for determining the target animal species, organs, and cell-types for IVA. ► The NS1 protein of IVA inhibits IFN-I production in virus-infected cells...