Correlation of protection against Japanese encephalitis virus and JE vaccine (IXIARO ®) induced neutralizing antibody titers

• Published in: Vaccine Vol. 29; no. 35; pp. 5925 - 5931
• Main Authors: Van Gessel, Yvonne, Klade, Christoph S., Putnak, Robert, Formica, Alessandra, Krasaesub, Somporn, Spruth, Martin, Cena, Bruno, Tungtaeng, Anchalee, Gettayacamin, Montip, Dewasthaly, Shailesh
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 11.08.2011; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Animals; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; antiserum; Applied microbiology; Arboviral encephalitis; Arboviroses; Automation; Biological and medical sciences; blood serum; Brain research; Cell culture; clinical trials; Correlation; Dilution; Encephalitis Virus, Japanese - immunology; Encephalitis Virus, Japanese - pathogenicity; Encephalitis, Japanese - immunology; Encephalitis, Japanese - mortality; Encephalitis, Japanese - prevention & control; Encephalitis, Japanese - virology; Female; Fundamental and applied biological sciences. Psychology; genotype; Human viral diseases; Humans; Immune Sera - administration & dosage; Immune Sera - immunology; Immunization; Immunization, Passive; Infectious diseases; Ixiaro; Japanese encephalitis; Japanese Encephalitis Vaccines - administration & dosage; Japanese Encephalitis Vaccines - immunology; Japanese encephalitis virus; lethal dose; Male; Medical sciences; Mice; Mice, Inbred ICR; Microbiology; Miscellaneous; Neutralization; Neutralization Tests; neutralizing antibodies; Protection; Survival Analysis; Treatment Outcome; Tropical viral diseases; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vector-borne diseases; Viral diseases; Virology; volunteers; Thailand; North America; Europe; India; Ixiaro; Correlation; Vaccine; Protection; Japanese encephalitis; Nervous system diseases; Flavivirus; Neutralizing antibody; Cerebral disorder; Infection; Virus; Viral disease; Arbovirus disease; Central nervous system disease; Japanese encephalitis virus; Japanese encephalitis group virus; Flaviviridae; Quantitative analysis

Immune sera from volunteers vaccinated in a blinded Phase 3 clinical trial with JE-VAX ® and a new Japanese encephalitis virus (JEV) vaccine (IC51 or IXIARO), were tested for the ability to protect mice against lethal JEV challenge. Sera from IXIARO vaccinated subjects were pooled into four batches...