Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™)

• Published in: Vaccine Vol. 36; no. 26; pp. 3779 - 3788
• Main Authors: Fernando, Germain J.P., Hickling, Julian, Jayashi Flores, Cesar M., Griffin, Paul, Anderson, Christopher D., Skinner, S. Rachel, Davies, Cristyn, Witham, Katey, Pryor, Melinda, Bodle, Jesse, Rockman, Steve, Frazer, Ian H., Forster, Angus H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 18.06.2018; Elsevier Limited
• Subjects: Acceptability; Administration, Cutaneous; Adolescent; Adult; Allergy and Immunology; antibodies; Antibodies, Viral - blood; Antigens; arms (limbs); Clinical trial; Clinical trials; Coating; Coatings; Dosage; Drug delivery systems; Drug-Related Side Effects and Adverse Reactions; Excipients; fearfulness; Female; Forearm; freeze drying; geometry; health care workers; Healthy Volunteers; hemagglutination; Hemagglutination inhibition; Hemagglutination Inhibition Tests; Hemagglutinins; Humans; Immune response; Immunization; Immunogenicity; Influenza; influenza vaccines; Influenza Vaccines - administration & dosage; Influenza Vaccines - adverse effects; Influenza Vaccines - immunology; Influenza, Human - prevention & control; Injection; Injections, Intramuscular; Male; Medical personnel; Medical research; Microarray patch; microarray technology; Microneedle patch; Middle Aged; Nanopatch; Needles; Orthomyxoviridae; Patient Acceptance of Health Care; Pine needles; placebos; Placebos - administration & dosage; risk; Silicon wafers; Single-Blind Method; Skin; skin (animal); Transcutaneous vaccination; vaccination; Vaccines; Vaccines, Inactivated - administration & dosage; Vaccines, Inactivated - adverse effects; Vaccines, Inactivated - immunology; Viruses; volunteers; Workers; Young Adult; Singapore; California; Queensland Australia; Australia; United States > US; Clinical trial; Microarray patch; Transcutaneous vaccination; Influenza; Microneedle patch; Nanopatch

Injection using needle and syringe (N&S) is the most widely used method for vaccination, but requires trained healthcare workers. Fear of needles, risk of needle-stick injury, and the need to reconstitute lyophilised vaccines, are also drawbacks. The Nanopatch (NP) is a microarray skin patch com...