Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 362; no. 1481; pp. 917 - 932
• Main Author: Robbins, T.W
• Format: Journal Article
• Language: English
• Published: London The Royal Society 29.05.2007
• Subjects: Attention; Basal Ganglia - physiology; Behavioral neuroscience; Brain damage; Callithrix; Corpus Striatum - physiology; Discrimination learning; Humans; Inhibition; Learning; Lesions; Magnetic resonance imaging; Neuropsychology; Neurotransmitter Agents - physiology; Neurotransmitters; Parkinson disease; Prefrontal Cortex; Prefrontal Cortex - physiology; Striatum; Switching; Working memory

The neuropsychological basis of attentional set-shifting, task-set switching and stop-signal inhibition is reviewed through comparative studies of humans and experimental animals. Using human functional neuroimaging, plus neuropsychological investigation of patients with frontal damage quantified by...