Ferroptosis in Parkinson’s disease: glia–neuron crosstalk

• Published in: Trends in molecular medicine Vol. 28; no. 4; pp. 258 - 269
• Main Authors: Wang, Zhang-Li, Yuan, Lin, Li, Wen, Li, Jia-Yi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2022
• Subjects: alpha-Synuclein - metabolism; Basic Medicine; Cell Death - physiology; Dopaminergic Neurons - metabolism; Ferroptosis; glia; Humans; iron; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Neuroglia - metabolism; neuron; Neurosciences; Neurovetenskaper; Parkinson Disease - metabolism; Parkinson's disease; neuron; iron; Parkinson's disease; ferroptosis; glia

Parkinson’s disease (PD) is characterized by dopaminergic (DA) neuron loss and the formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is unknown, iron dyshomeostasis has been proposed as a potential contributing factor. Emerging evidence suggests that glial cell activ...