Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN

• Published in: Molecular metabolism (Germany) Vol. 39; p. 101012
• Main Authors: Alves, Christiano R.R., Neves, Willian das, de Almeida, Ney R., Eichelberger, Eric J., Jannig, Paulo R., Voltarelli, Vanessa A., Tobias, Gabriel C., Bechara, Luiz R.G., de Paula Faria, Daniele, Alves, Maria J.N., Hagen, Lars, Sharma, Animesh, Slupphaug, Geir, Moreira, José B.N., Wisloff, Ulrik, Hirshman, Michael F., Negrão, Carlos E., de Castro Jr, Gilberto, Chammas, Roger, Swoboda, Kathryn J., Ruas, Jorge L., Goodyear, Laurie J., Brum, Patricia C.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.09.2020; Elsevier
• Subjects: Animals; Atrophy; Biomarkers; Cachexia - etiology; Cachexia - metabolism; Cancer cachexia; Cell Line, Tumor; COP9 Signalosome Complex - genetics; COP9 Signalosome Complex - metabolism; Cytokines - metabolism; Disease Models, Animal; Endurance exercise; Energy Metabolism; Gene Knockdown Techniques; Humans; Male; Mice; Muscle Fibers, Skeletal - metabolism; Muscle wasting; Muscle, Skeletal - metabolism; Muscular Atrophy - etiology; Muscular Atrophy - metabolism; Myoblasts - metabolism; Neoplasms - complications; Neoplasms - metabolism; Original; Oxidation-Reduction; Oxidative Stress; Physical Conditioning, Animal; Proteomics - methods; Rats; Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics; Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism; Repressor Proteins - genetics; Repressor Proteins - metabolism; Response elements; Signal Transduction; Atrophy; Endurance exercise; Cancer cachexia; Muscle wasting; Response elements

We tested the hypothesis that exercise training would attenuate metabolic impairment in a model of severe cancer cachexia. We used multiple in vivo and in vitro methods to explore the mechanisms underlying the beneficial effects induced by exercise training in tumor-bearing rats. Exercise training i...